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Research Project: Intervention Strategies to Control and Eradicate Foreign Animal Diseases of Swine

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Title: African swine fever virus p72 identification tool

item Dinhobl, Mark
item Spinard Iii, Edward
item BIRTLEY, HILLARY - Oak Ridge Institute For Science And Education (ORISE)
item TESLER, NICOLAS - Oak Ridge Institute For Science And Education (ORISE)
item MASEMBE, CHARLES - Makerere University
item Borca, Manuel
item Gladue, Douglas

Submitted to: Microbiology Resource Announcements
Publication Type: Other
Publication Acceptance Date: 12/1/2023
Publication Date: 1/8/2024
Citation: Dinhobl, M.W., Spinard III, E.J., Birtley, H., Tesler, N., Masembe, C., Borca, M.V., Gladue, D.P. 2024. African swine fever virus p72 identification tool. Microbiology Resource Announcements. 13(2). Article e00891-23.

Interpretive Summary: African swine fever virus (ASFV) is currently causing a world-wide pandemic of a highly lethal disease in domestic swine and wild boar. It was previously believed that there were over 25 genotypes of ASFV, as new sequencing and analysis techniques have advanced since the first discovery of ASFV, due to the difficulties in genotyping we developed a tool that incorporates the correct genotypes of ASFV by simple user input of p72 sequence.

Technical Abstract: Historically, genotyping of African swine fever virus was based on partial sequencing of B646L (p72). Until recently, the number of differences that defined genotypes was ambiguous. This tool allows a sequence to be uploaded and will report its closest matches along with its likely p72 genotype.