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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Infectious Bacterial Diseases Research » Research » Publications at this Location » Publication #391172

Research Project: Identification of Antigens and Host Innate Immune Responses for Control of Johne's Disease

Location: Infectious Bacterial Diseases Research

Title: Challenges in veterinary vaccine development

item THOMAS, SUNIL - Lankenau Institute For Medical Research
item ABRAHAM, ANN - Lankenau Institute For Medical Research
item RODRIGUEZ-MALLON, ALINA - Center For Genetic Engineering And Biotechnology (CIGB)
item UNAJAK, SASIMANAS - Kasetsart University
item Bannantine, John

Submitted to: Methods in Molecular Biology
Publication Type: Book / Chapter
Publication Acceptance Date: 11/1/2021
Publication Date: 11/24/2021
Citation: Thomas, S., Abraham, A., Rodriguez-Mallon, A., Unajak, S., Bannantine, J.P. 2021. Challenges in veterinary vaccine development. In: Thomas, S., editor. Vaccine Design. NY, NY: Humana. 1124. p. 3-36.

Interpretive Summary: The review article provides a summary of the distinct challenges associated with vaccinating different animal species against disease. Species that were discussed include poultry, companion animals, cattle, sheep, and goats. Challenges include cost, dose, diagnostic interference and many other species-specific issues. In several instances, solutions are proposed for these challenges. This article is of interest to animal producers, veterinarians, and scientists working in the animal health field.

Technical Abstract: Animals provide food and clothing in addition to other value-added products. Changes in diet and lifestyle have increased the consumption and the use of animal products. Infectious diseases in animals are a major threat to global animal health and its welfare; their effective control is crucial for agronomic health, for safeguarding food security and also alleviating rural poverty. Development of vaccines has led to increased production of healthy poultry, livestock, and fish. Animal production increases have alleviated food insecurity. In addition, development of effective vaccines has led to healthier companion animals. However, challenges remain including climate change that has led to enhancement in vectors and pathogens that may lead to emergent diseases in animals. Preventing transmission of emerging infectious diseases at the animal–human interface is critically important for protecting the world population from epizootics and pandemics. Hence, there is a need to develop new vaccines to prevent diseases in animals. This describes the broad challenges to be considered in the development of vaccines for animals.