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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Infectious Bacterial Diseases Research » Research » Publications at this Location » Publication #390549

Research Project: Diagnostic and Mitigation Strategies to Control Tuberculosis in Cattle and Wildlife

Location: Infectious Bacterial Diseases Research

Title: The bovine tuberculoid granuloma

Author
item Palmer, Mitchell
item Kanipe, Carly
item Boggiatto, Paola

Submitted to: Pathogens
Publication Type: Review Article
Publication Acceptance Date: 12/30/2021
Publication Date: 1/4/2022
Citation: Palmer, M.V., Kanipe, C.R., Boggiatto, P.M. 2022. The bovine tuberculoid granuloma. Pathogens. https://doi.org/10.3390/pathogens11010061.
DOI: https://doi.org/10.3390/pathogens11010061

Interpretive Summary: The bacterium, Mycobacterium bovis causes tuberculosis in most animal including humans. The disease caused by M. bovis can be indistinguishable from that caused by M. tuberculosis, the more common cause of tuberculosis in humans. Cattle have sometimes been used as models to study human tuberculosis. Although both M. bovis and M. tuberculosis have existed for thousands of years, tuberculosis is still the leading cause of death to infectious disease. It is believed that understanding interactions of the bacteria with host tissues at the site of infection is critical to understanding tuberculosis. This review describes the development of hallmark tissue changes during the disease process.

Technical Abstract: The bovine tuberculoid granuloma is the hallmark lesion of bovine tuberculosis (bTB) due to Mycobacterium bovis infection. The pathogenesis of bTB, and thereby the process of bovine tuberculoid granuloma development, involves the recruitment, activation, and maintenance of cells under the influence of antigen, cytokines and chemokines in affected lungs and regional lymph nodes. The granuloma is key to successful control of bTB by preventing pathogen dissemination through containment by cellular and fibrotic layers. Paradoxically, however, it may also provide a niche for bacterial replication. The morphologic and cellular characteristics of granulomas have been used to gauge disease severity in bTB pathogenesis and vaccine efficacy studies. As such, it is critical to understand the complex mechanisms behind granuloma initiation, development, and maintenance