Location: Infectious Bacterial Diseases Research
Title: Complete genome sequence of a type III ovine strain of Mycobacterium avium subspecies paratuberculosisAuthor
BANNANTINE, JOHN | |
BAYLES, DARRELL | |
BIET, FRANCK - Université François-Rabelais De Tours |
Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 2/12/2021 Publication Date: 3/11/2021 Citation: Bannantine, J.P., Bayles, D.O., Biet, F. 2021. Complete genome sequence of a type III ovine strain of Mycobacterium avium subspecies paratuberculosis. Microbiology Resource Announcements. 10. https://doi.org/10.1128/MRA.01480-20. DOI: https://doi.org/10.1128/MRA.01480-20 Interpretive Summary: Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease in farmed livestock, including cattle, sheep and goats. The genome of the first type III sheep strain of MAP was sequenced and assembled to complete closure. Previously, type II bovine strains and a type I sheep strain were sequenced to completion and available publicly, but no type III strains. This new information will unlock the genetic diversity this exists within MAP to help us understand host preferences and evolution of this veterinary pathogen. Finally, this new sequence will better inform diagnostic targets. Technical Abstract: The complete genome sequence of the first type III strain of Mycobacterium avium subspecies paratuberculosis was determined. The genome size for this pathogen of sheep is 4,895,755 bp with no plasmid DNA. The chromosome contains 19 copies of the hallmark IS900 element, which is routinely used to identify this subspecies. |