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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #367812
Research Project: Non-Antibiotic Strategies to Control Priority Bacterial Infections in Swine

Location: Virus and Prion Research

Title: Complete genome sequence of Bordetella bronchiseptica strain KM22

Author
item Nicholson, Tracy
item Bayles, Darrell
item Shore, Sarah

Submitted to: Microbiology Resource Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/26/2019
Publication Date: 1/23/2020
Citation: Nicholson, T.L., Bayles, D.O., Shore, S. 2020. Complete genome sequence of Bordetella bronchiseptica strain KM22. Microbiology Resource Announcements. 9(4). https://doi.org/10.1128/MRA.01207-19.
DOI: https://doi.org/10.1128/MRA.01207-19

Interpretive Summary: Numerous studies have demonstrated that Bordetella pertussis and Bordetella parapertussis, causative agents of pertussis, commonly called whooping cough, evolved independently from Bordetella bronchiseptica. As a result B. pertussis and B. parapertussis represent two out of the many examples of human pathogens that evolved from zoonotic sources. B. bronchiseptica strain KM22 has been used in experimental infections of swine as a model of clinical B. bronchiseptica infection and to study host-to-host transmission. Here, we report the complete genome sequence of KM22. This information can be directly used to design improved vaccines and therapeutic interventions to eradicate B. bronchiseptica from swine herds that do not rely on antimicrobial use. Additionally, the information in this report can be used by other scientists to investigate mechanism used by bacterial pathogens to generate phenotypic diversity, infection, and transmission among hosts.

Technical Abstract: Numerous studies have demonstrated that Bordetella pertussis and Bordetella parapertussis, causative agents of pertussis, commonly called whooping cough, evolved independently from Bordetella bronchiseptica. As a result B. pertussis and B. parapertussis represent two out of the many examples of human pathogens that evolved from zoonotic sources. B. bronchiseptica strain KM22 has been used in experimental infections of swine as a model of clinical B. bronchiseptica infection and to study host-to-host transmission. Here, we report the complete genome sequence of KM22. This information can be directly used to design improved vaccines and therapeutic interventions to eradicate B. bronchiseptica from swine herds that do not rely on antimicrobial use. Additionally, the information in this report can be used by other scientists to investigate mechanism used by used by bacterial pathogens to generate phenotypic diversity, infection, and transmission among hosts.