Location: Plant Science ResearchTitle: Fine-tuning immunity: Players and regulators for plant NLRs
|SUN, YANG - Shandong University|
|ZHU, YUXIU - Shandong University|
|WANG, GUAN-FENG - Shandong University|
Submitted to: Trends in Plant Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/17/2020
Publication Date: 3/17/2020
Citation: Sun, Y., Zhu, Y., Balint Kurti, P.J., Wang, G. 2020. Fine-tuning immunity: Players and regulators for plant NLRs. Trends in Plant Science. https://doi.org/10.1016/j.tplants.2020.02.008.
Interpretive Summary: Plant resistance proteins both recognize a pathogen and induce a strong resistance response that can be detrimental to plant growth if improperly regulated. Here we review proteins that interact with resistance proteins in plant to fine-tune their activity.
Technical Abstract: To defend against pathogen infection, plants have evolved a sophisticated innate immune system. One of the main components of this system are the intracellular nucleotide binding, leucine-rich repeat (NLR) immune receptors. NLR activity is fine-tuned by intra- and inter-molecular interactions. In this review, we survey what is known about the conservation and diversity of NLR-interacting proteins which we have termed NLR regulators and divide into six major categories. We discuss the molecular mechanisms by which they regulate NLR activity and how the understanding of this regulation has the potential to facilitate the engineering of novel NLRs for crops.