Location: Animal Disease Research
Title: Babesiosis vaccines: Lessons learned, challenges ahead, and future glimpsesAuthor
RATHINASAMY, VIGNESH - WASHINGTON STATE UNIVERSITY | |
POOLE, WILLIAM - WASHINGTON STATE UNIVERSITY | |
BASTOS, REGINALDO - WASHINGTON STATE UNIVERSITY | |
SUAREZ, CARLOS | |
COOKE, BRIAN - WASHINGTON STATE UNIVERSITY |
Submitted to: Trends in Parasitology
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 9/4/2019 Publication Date: 9/12/2019 Citation: Rathinasamy, V., Poole, W.A., Bastos, R.G., Suarez, C.E., Cooke, B.M. 2019. Babesiosis vaccines: Lessons learned, challenges ahead, and future glimpses. Trends in Parasitology. 35(8):622-635. https://doi.org/10.1016/j.pt.2019.06.002. DOI: https://doi.org/10.1016/j.pt.2019.06.002 Interpretive Summary: The incidence and prevalence of babesiosis in animals and humans is increasing yet prevention, control or treatment measures remain limited and ineffective. Despite a growing body of new knowledge of the biology, pathogenicity and virulence mechanisms of babesia parasites, there is still no well-defined, adequately effective and easily deployable vaccine. While numerous published studies suggest that the development of such vaccines should be feasible, many others identify significant challenges that need to be overcome in order to succeed. Here, we review historic and recent and attempts in babesiosis vaccine discovery to avoid past pitfalls, learn new lessons and provide a roadmap to guide the development of next-generation babesiosis vaccines. Technical Abstract: The incidence and prevalence of babesiosis in animals and humans is increasing yet prevention, control or treatment measures remain limited and ineffective. Despite a growing body of new knowledge of the biology, pathogenicity and virulence mechanisms of babesia parasites, there is still no well-defined, adequately effective and easily deployable vaccine. While numerous published studies suggest that the development of such vaccines should be feasible, many others identify significant challenges that need to be overcome in order to succeed. Here, we review historic and recent and attempts in babesiosis vaccine discovery to avoid past pitfalls, learn new lessons and provide a roadmap to guide the development of next-generation babesiosis vaccines. |