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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Food Safety and Enteric Pathogens Research » Research » Publications at this Location » Publication #355002

Research Project: Intestinal Microbial Ecology and Metagenomic Strategies to Reduce Antibiotic Resistance and Foodborne Pathogens

Location: Food Safety and Enteric Pathogens Research

Title: Complete genome sequence of the multi-drug resistant neonatal meningitis Escherichia coli serotype O75:H5:K1 strain mcjchv-1 (NMEC-O75)

Author
item Nielsen, Daniel - Iowa State University
item Ricker, Nicole - Orise Fellow
item Barbieri, Nicolle - University Of Georgia
item Wynn, James - University Of Florida
item Gomez-duarte, Oscar - State University Of New York- College Of Environmental Science And Forestry
item Iqbal, Junaid - State University Of New York- College Of Environmental Science And Forestry
item Nolan, Lisa - University Of Georgia
item Allen, Heather
item Logue, Catherine - University Of Georgia

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/7/2018
Publication Date: 9/13/2018
Citation: Nielsen, D.W., Ricker, N., Barbieri, N.L., Wynn, J., Gomez-Duarte, O.G., Iqbal, J., Nolan, L.K., Allen, H.K., Logue, C.M. 2018. Complete genome sequence of the multi-drug resistant neonatal meningitis Escherichia coli serotype O75:H5:K1 strain mcjchv-1 (NMEC-O75). Genome Announcements. 7(10):e01043-18. https://doi.org/10.1128/MRA.01043-18.
DOI: https://doi.org/10.1128/MRA.01043-18

Interpretive Summary: Sequencing the genome of bacteria that have been isolated in culture is a powerful way to get a lot of information about them in a short amount of time. In this study we report the full genome sequence of new strain of Escherichia coli that causes neonatal meningitis in infants. This genome is of interest to scientists and stakeholders who study emerging meningitis-causing strains of E. coli.

Technical Abstract: Neonatal meningitis Escherichia coli (NMEC) is the second-leading cause of neonatal bacterial meningitis (NBM) worldwide. Here, we report the genome sequence of a multi-drug resistant, NMEC serotype O75:H5:K1 strain mcjchv-1, which resulted in the death of an infant. The O75 serogroup is rare among NMEC isolates; therefore, this strain is considered an emergent pathogen.