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ARS Home » Southeast Area » Little Rock, Arkansas » Microbiome and Metabolism Research Unit » Research » Publications at this Location » Publication #347504

Title: Prenatal phthalate metabolite concentrations and infant fat mass across the first year of life: A pilot study

item JAMES-TODD, TAMARRA - Harvard School Of Public Health
item HULL, HOLLY - Kansas State University
item ANDRES, ALINE - Arkansas Children'S Nutrition Research Center (ACNC)

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 9/1/2017
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Phthalates are endocrine-disrupting chemicals associated with childhood obesity. While studies have found positive associations for certain prenatal and postnatal urinary phthalate metabolites and weight/length or BMI as indicators of adiposity levels, little is known about the direct associations between phthalates and fat accretion in early life. This study measured prenatal phthalate urine metabolite concentrations and infant fat mass (FM) across 12-months. Using a prospective design, a total of 20 white mothers were included based on their pre-pregnancy body mass index (BMI) and FM (n=10 obese: >30kg/m2and >30% FM; n=10 normal weight: <25kg/m2 and <30% FM). Urine was collected at 30 weeks gestation and analyzed for 9 urinary phthalate metabolites and divided at the median. Children's FM were obtained at 2-weeks, 6-months, and 12-months of age using quantitative magnetic resonance. ANOVA and generalized linear models evaluated the associations between prenatal phthalate metabolite concentrations and infant FM measures, while adjusting for potential confounders (maternal BMI, FM, and gestational weight gain). Higher than median concentrations of mono-(3-carboxypropyl) phthalate (MCPP) was associated with higher infant FM at 6-months and 12-months of age (p<0.03). Higher mono-ethyl phthalate (MEP) concentrations were associated with lower infant FM at 12 months (p=0.008). After adjusting for confounders, infants born to mothers with > median MCPP levels had a 4.2% higher FM at 12-months compared to infants born to mothers with