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ARS Home » Southeast Area » Gainesville, Florida » Center for Medical, Agricultural and Veterinary Entomology » Mosquito and Fly Research » Research » Publications at this Location » Publication #344236

Research Project: Biting Arthropod Surveillance and Control

Location: Mosquito and Fly Research

Title: Chemical composition of Buddleja polystachya aerial parts and its bioactivity against Aedes aegypti

Author
item El-gamal, Ali - King Saud University
item Al-massarani, Shaza - King Saud University
item Fawzy, Ghada - King Saud University
item Atai, Hanan - King Saud University
item Al-rehaily, Adnan - King Saud University
item Basudan, Omer - King Saud University
item Abdel-kader, Maged - Sattam Bin Abdulaziz University
item Tabanca, Nurhayat
item Becnel, James

Submitted to: Natural Product Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/29/2017
Publication Date: 9/25/2017
Citation: El-Gamal, A., Al-Massarani, S., Fawzy, G., Atai, H., Al-Rehaily, A., Basudan, O., Abdel-Kader, M., Tabanca, N., Becnel, J.J. 2017. Chemical composition of Buddleja polystachya aerial parts and its bioactivity against Aedes aegypti. Natural Product Research. doi:10.1080/14786419.2017.1378213.
DOI: https://doi.org/10.1080/14786419.2017.1378213

Interpretive Summary: Chemical study of the aerial parts and flowers of the plant Buddleja polystachya has identified one new compound in addition to 18 known compounds. Mosquitoes have become highly resistant to the most commonly used pesticides and there is a pressing need for compounds with alternative modes of action. Primary bioassays found that the compounds were not active against Aedes aegypti first instar larvae but had better adulticidal activity, therefore the isolated compounds were only tested against adult mosquitoes. One compound (phytol) was highly active against Aedes aegypti adults and additional studies are required to determine activity against other mosquito species and possible use for mosquito control.

Technical Abstract: A new acylatediridoid glycoside, 6-O-a-L-(2''-acetyl-4''-O-trans-isoferuloyl) rhamnopyranosyl catalpol (9) together with 18 known compounds belonging to the iridoids, flavonoids, triterpene saponin glycosides and phenylethanoids (1-8, 10-18) were isolated from the aerial parts and the flowers of Buddleja polystachya. Their structures were elucidated on the basis of spectroscopic evidence and comparison with that reported in the literature. Promising adulticidal activity was shown for all extracts when tested for adulticidal and larvicidal activities against Ae. aegypti mosquitoes. Therefore, isolated compounds (1-10, 12-14 and 19) were bioassayed for their adulticidal activity. Compound 1 (phytol) was highly active with an LD50 value of 1.27±0.08 µg/mosquito against adult female Ae. aegypti.