Location: Virus and Prion ResearchTitle: Draft genome sequences of 50 MRSA ST5 isolates obtained from a U.S. hospital Author
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/6/2017
Publication Date: 11/2/2017
Citation: Hau, S.J., Bayles, D.O., Alt, D.P., Nicholson, T.L. 2017. Draft genome sequences of 50 methicillin-resistant Staphylococcus aureus sequence type 5 isolates obtained from a U.S. hospital. Genome Announcements. 5(44):e01083-17.
Interpretive Summary: Livestock associated methicillin-resistant Staphylococcus aureus (LA-MRSA) draws concern from the public health community because it is considered the largest reservoir of MRSA outside hospital settings. Recent studies indicate LA-MRSA strains from swine are more genetically diverse than the first reported sequence type ST398. In the US, a diverse population of LA-MRSA is found including organisms of the ST398, ST9, and ST5 lineages. Occurrence of ST5 MRSA in swine is of particular concern since ST5 is among the most prevalent lineages causing clinical infections in humans. The ability of ST5 isolates to cause disease in humans is believed to result from acquisition of mobile genetic elements encoding virulence or host-adapted genes. Here, we report the generation of 48 draft genome sequences from MRSA ST5 isolates obtained from the hospital at the University of California, Irvine. This information can be directly used to search for mobile genetic elements encoding virulence or host-adapted genes. More importantly, the data reported here can be used to determine how genetically related are the ST5 isolates obtained from swine to ST5 isolates obtained from humans. This information is important to public health professional, veterinarians, producers, and consumers.
Technical Abstract: Methicillin resistant Staphylococcus aureus (MRSA) can be a commensal or pathogen in humans. Pathogenicity and disease are related to the acquisition of mobile genetic elements encoding virulence and antimicrobial resistance genes. Here, we report draft genome sequences for 50 clinical MRSA isolates from humans with MRSA related disease.