Location: Virus and Prion ResearchTitle: Draft genome sequences of 14 swine associated LA-MRSA ST398 isolates from the U.S.
|HAU, SAMANTHA - Iowa State University
|FRANA, TIMOTHY - Iowa State University
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/1/2017
Publication Date: 11/2/2017
Citation: Hau, S.J., Bayles, D.O., Alt, D.P., Frana, T.S., Nicholson, T.L. 2017. Draft genome sequences of 14 livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 isolates from swine farms in the United States. Genome Announcements. 5(44):e01082-17.
Interpretive Summary: Livestock associated methicillin-resistant Staphylococcus aureus (LA-MRSA) draws concern from the public health community because it is considered the largest reservoir of MRSA outside hospital settings. While ST398 is generally considered a livestock adapted lineage, there have been reports of colonization and infection of humans with LA-MRSA ST398 isolates. To address the concerns surrounding LA-MRSA ST398, genetic studies have evaluated isolate relatedness and found that LA-MRSA ST398 is likely derived from a methicillin sensitive ST398 lineage from humans. Detection of genetic changes and potential for human outbreaks with LA-MRSA ST398 isolates relies on continuing evaluation of genomic data from LA-MRSA field isolates. Here, we present 14 draft genome sequence from LA-MRSA ST398 isolates obtained from healthy pigs or the environment within three high density livestock operations in the US. This information can be directly used to search for mobile genetic elements encoding virulence or host-adapted genes. This information is important to public health professional, veterinarians, producers, and consumers.
Technical Abstract: Livestock associated methicillin resistant Staphylococcus aureus (LA-MRSA) is part of the normal microbiota of swine. The initial and predominant swine associated LA-MRSA sequence type (ST) identified is ST398. Here, we present 14 draft genome sequence from LA-MRSA ST398 isolates found in the US.