Location: Virus and Prion ResearchTitle: Draft genome sequences of 64 swine associated LA-MRSA ST5 isolates from the USA
|HAU, SAMANTHA - Iowa State University
|FRANA, TIMOTHY - Iowa State University
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/27/2017
Publication Date: 11/2/2017
Citation: Hau, S.J., Bayles, D.O., Alt, D.P., Frana, T.S., Nicholson, T.L. 2017. Draft genome sequences of 63 swine-associated methicillin-resistant Staphylococcus aureus sequence type 5 isolates from the United States. Genome Announcements. 5(44):e01081-17.
Interpretive Summary: Swine populations in the US harbor a mixed population of livestock associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates with the sequence type (ST) 398, ST9, and ST5 lineages being detected. LA-MRSA ST5 isolates are particularly concerning to the public health community because, while the ST398 and ST9 lineage are considered livestock adapted and are thought to be less able to colonize and cause disease in humans, the ST5 lineage is globally disseminated and a significant cause of disease in both the hospital and community setting. The ability of ST5 isolates to cause disease in humans is believed to result from acquisition of mobile genetic elements encoding virulence or host-adapted genes. In this report, we present the draft genome sequences of 64 LA-MRSA ST5 isolates obtained from healthy pigs and the environment of eight high density livestock operations. This information can be directly used to search for mobile genetic elements encoding virulence or host-adapted genes. This information is important to public health professional, veterinarians, producers, and consumers.
Technical Abstract: Methicillin resistant Staphylococcus aureus colonizes humans and other animals such as swine. LA-MRSA sequence type (ST) 5 isolates are a public concern due to their pathogenicity and ability to acquire mobile genetic elements. This report presents draft genome sequences for 64 LA-MRSA ST5 isolates in the US.