Location: Virus and Prion ResearchTitle: Complete genome sequence of a swine associated LA-MRSA ST5 isolate from the USA
|HAU, SAMANTHA - Iowa State University|
|FRANA, TIMOTHY - Iowa State University|
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 6/27/2017
Publication Date: 8/10/2017
Citation: Hau, S.J., Bayles, D.O., Alt, D.P., Frana, T.S., Nicholson, T.L. 2017. Complete genome sequence of a swine associated LA-MRSA ST5 isolate from the USA. Genome Announcements. 5(32):e00791-17. https://doi.org/10.1128%2FgenomeA.00791-17.
Interpretive Summary: Livestock associated methicillin-resistant Staphylococcus aureus (LA-MRSA) draws concern from the public health community because it is considered the largest reservoir of MRSA outside hospital settings. Recent studies indicate LA-MRSA strains from swine are more genetically diverse than the first reported sequence type ST398. In the US, a diverse population of LA-MRSA is found including organisms of the ST398, ST9, and ST5 lineages. Occurrence of ST5 MRSA in swine is of particular concern since ST5 is among the most prevalent lineages causing clinical infections in humans. The ability of ST5 isolates to cause disease in humans is believed to result from acquisition of mobile genetic elements encoding virulence or host-adapted genes. Here, we report the complete genome sequence of a swine LA-MRSA ST5 isolate from the US. This information can be directly used to search for mobile genetic elements encoding virulence or host-adapted genes. This information is important to public health professional, veterinarians, producers, and consumers.
Technical Abstract: Livestock associated methicillin resistant Staphylococcus aureus (LA-MRSA) may be the largest MRSA reservoir outside the hospital setting. One concern with LA-MRSA is the acquisition of novel mobile genetic elements by these isolates. Here, we report the complete genome sequence of a swine LA-MRSA ST5 isolate from the US.