Location: Virus and Prion ResearchTitle: Complete genome sequence of livestock associated methicillin resistant Staphylococcus aureus ST398 isolated from swine in USA
|HAU, SAMANTHA - Iowa State University|
|FRANA, TIMOTHY - Iowa State University|
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 6/27/2017
Publication Date: 8/10/2017
Citation: Hau, S.J., Bayles, D.O., Alt, D.P., Frana, T.S., Nicholson, T.L. 2017. Complete genome sequence of livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 isolated from swine in the United States. Genome Announcements. 5(32):pii: e00790-17. https://doi.org/10.1128/genomeA.00790-17.
Interpretive Summary: Livestock associated methicillin-resistant Staphylococcus aureus (LA-MRSA) draws concern from the public health community because it is considered the largest reservoir of MRSA outside hospital settings. Recent studies indicate LA-MRSA strains from swine are more genetically diverse than the first reported sequence type ST398. The ST398 lineage has been identified in a variety of livestock species and is considered to be adapted to colonization of non-human mammals, although colonization and infection has been noted in humans. The ability to cause disease in humans is believed to result from acquisition of mobile genetic elements encoding virulence or host-adapted genes. Here, we report the complete genome sequence of a swine LA-MRSA ST398 isolate from the nose of a healthy pig in the US. This information can be directly used to search for mobile genetic elements encoding virulence or host-adapted genes. This information is important to public health professional, veterinarians, producers, and consumers.
Technical Abstract: Methicillin resistant Staphylococcus aureus colonizes and causes disease in many animal species. Livestock associated-MRSA isolates are represented by isolates of the sequence type 398. These isolates are considered to be livestock adapted. This report provides the complete genome of one swine associated LA-MRSA ST398 isolate from the USA.