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ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Obesity and Metabolism Research » Research » Publications at this Location » Publication #329386
Title: Thiamin-fortified fish sauce: a novel means of increasing erythrocyte and breast milk thiamin concentratins among rural Cambodian women and their infants

Author
item WHITFIELD, KYLY - University Of British Columbia
item KARAKOCHUK, CRYSTAL - University Of British Columbia
item KROEUN, HOU - Helen Keller International (HKI), United States
item SOKHOING, LY - Helen Keller International (HKI), United States
item HAMPEL, DANIELA - University Of California
item CHAN, BENNY - Ministry Of Planning-Cambodia
item SOPHONNEARY, PRAK - Ministry Of Planning-Cambodia
item TALUKDER, AMINUZZAMAN - Helen Keller International (HKI), United States
item MCLEAN, JUDY - University Of British Columbia
item LYND, LARRY - University Of British Columbia
item LI-CHAN, EUNICE C. - University Of British Columbia
item KITTS, DAVID - University Of British Columbia
item Allen, Lindsay - A
item GREEN, TIMOTHY - University Of British Columbia

Submitted to: Micronutrient Forum Global Conference
Publication Type: Abstract Only
Publication Acceptance Date: 10/25/2016
Publication Date: 10/25/2016
Citation: Whitfield, K.C., Karakochuk, C.C., Kroeun, H., Sokhoing, L., Hampel, D., Chan, B.B., Sophonneary, P., Talukder, A., Mclean, J., Lynd, L.D., Li-Chan, E.Y., Kitts, D.D., Allen, L.H., Green, T.J. 2016. Thiamin-fortified fish sauce: a novel means of increasing erythrocyte and breast milk thiamin concentratins among rural Cambodian women and their infants [abstract]. Micronutrient Forum Global Conference. Micronutrient Forum Global Conference, Cancun, Mexico, October 24-28, 2016.

Interpretive Summary:

Technical Abstract: Objectives: Infantile beriberi exists in Cambodia. Low maternal thiamin intake reduces breast milk thiamin concentrations, placing breastfed infants at risk of this potentially fatal disease. We aimed to determine if ad libitum consumption of thiamin-fortified fish sauce yielded higher erythrocyte thiamin diphosphate concentrations (eTDP) among women (18-45y) and their newborn infants, and higher breast milk thiamin concentrations, compared to a control sauce. Methods: In this double-blind, randomized controlled efficacy trial 90 women in Prey Veng, Cambodia were randomized to receive low (LC, 2g/L) or high concentration (HC, 8g/L) thiamin-fortified, or control (no thiamin) fish sauce. Maternal eTDP concentration was assessed at baseline and endline; breast milk thiamin and infant eTDP were measured at endline. Differences between treatment groups were assessed using general linear models. Results: Women were 23 ± 7wk pregnant at enrollment. Household fish sauce consumption was similar across treatment groups (p=0.07). Baseline-adjusted endline eTDP (estimated marginal mean; 95% CI) was higher among women in LC (276; 246, 306nM) and HC (238; 207, 268nM) groups versus control (194; 163, 224nM; p<0.05). Breast milk total thiamin was higher among women in LC (211; 187, 236µg/L) and HC groups (180; 152, 209µg/L) versus control (136; 110, 162µg/L; p<0.05). Infants of HC group mothers had higher eTDP (257; 215, 298nM; p<0.05) compared to LC (205; 175, 235nM) and control infants (181; 153, 210nM). Conclusions: Compared to control, women who consumed thiamin-fortified fish sauce through pregnancy and early lactation had higher eTDP and breast milk thiamin concentrations, and their breastfed infants had higher eTDP. (Funding: Grand Challenges Canada)