Skip to main content
ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Obesity and Metabolism Research » Research » Publications at this Location » Publication #326240

Research Project: Novel Functions and Biomarkers for Vitamins and Minerals

Location: Obesity and Metabolism Research

Title: Reply to Lawrence R. Solomon: Negative interaction of high folate status with biochemical and neurological response to vitamin B-12 treatment

Author
item BRITO, ALEX - University Of California
item FEDOSOV, SERGEY - Aarhus University
item MILLER, JOSHUA - Rutgers University
item GREEN, RALPH - University Of California
item UAUY, RICARDO - Universidad De Chile
item Allen, Lindsay - A

Submitted to: American Journal of Clinical Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/4/2016
Publication Date: 5/1/2016
Citation: Brito, A., Fedosov, S.N., Miller, J.W., Green, R., Uauy, R., Allen, L.H. 2016. Reply to Lawrence R. Solomon: Negative interaction of high folate status with biochemical and neurological response to vitamin B-12 treatment. American Journal of Clinical Nutrition. 103(5):1379. doi: 10.3945/ajcn.116.133322.

Interpretive Summary: We thank Dr. Lawrence Solomon for his observations and comments regarding our recent article on biochemical and neurological responses to vitamin B-12 treatment in asymptomatic Chilean elderly (1). Our article highlighted the most important effects of treatment; in our response to Dr. Solomon’s questions we provide additional details and analyses. Since this population was clinically “asymptomatic” we analyzed the neurophysiological data as continuous rather than as categorical variables.

Technical Abstract: We thank Dr. Lawrence Solomon for his observations and comments regarding our recent article on biochemical and neurological responses to vitamin B-12 treatment in asymptomatic Chilean elderly (1). Our article highlighted the most important effects of treatment; in our response to Dr. Solomon’s questions we provide additional details and analyses. Since this population was clinically “asymptomatic” we analyzed the neurophysiological data as continuous rather than as categorical variables.