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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Infectious Bacterial Diseases Research » Research » Publications at this Location » Publication #316896
Title: Complete genome sequence of Leptospira interrogans serovar Bratislava, strain PigK151

Author
item Alt, David
item Wilson-Welder, Jennifer
item Bayles, Darrell
item CAMERON, CAROLINE - University Of Victoria
item ADLER, BEN - Monash University
item BULACH, DIETER - Monash University
item SEEMANN, TORSTEN - Monash University
item LEHANE, MICHAEL - Liverpool School Of Tropical Medicine
item HAINES, LEE - Liverpool School Of Tropical Medicine
item DARBY, ALISTAIR - University Of Liverpool
item HALL, NEIL - University Of Liverpool
item RADFORD, ALAN - University Of Liverpool
item ZUERNER, RICHARD - Retired ARS Employee

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/20/2015
Publication Date: 6/25/2015
Citation: Alt, D.P., Wilson-Welder, J.H., Bayles, D.O., Cameron, C., Adler, B., Bulach, D.M., Seemann, T., Lehane, M.J., Haines, L.R., Darby, A.C., Hall, N., Radford, A.D., Zuerner, R.L. 2015. Complete genome sequence of Leptospira interrogans serovar Bratislava, strain PigK151. Genome Announcements. 3(3):e00678-15. DOI: 10.1128/genomeA.00678-15.

Interpretive Summary: Worldwide, leptospirosis is one of the most widespread zoonoses, with infection occurring in both domestic and wildlife species. Leptospria interrogans serovar Bratislava has been isolated from multiple species and is associated with poor reproductive performance in both pigs and horses. We present the complete genome assembly from strain PigK151, isolated from the kidney of a sow in Iowa. The availability of the complete genome sequence will allow comparison to other leptospiral genomes and provide a better understanding of the organism and potentially the infectious disease process in the host.

Technical Abstract: The genus Leptospira contains pathogens serologically classified into over 250 serovars, intermediate pathogens and saprophytes with genetic classification into 21 different species. Worldwide, leptospirosis is one of the most widespread zoonoses. L. interrogans serovar Bratislava has been isolated from both free-living and domestic species, swine with reproductive problems, dogs with renal disease and horses. In horses, poor reproductive performance has been linked with seroreactivity. We present the complete genome assembly of strain PigK151, an isolate of L. interrogans serovar Bratislava obtained from the kidney of a sow in Iowa. The genome contains two chromosomes CI (4.457 Mbp) and CII (358 kbp).