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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Genetics, Breeding, and Animal Health Research » Research » Publications at this Location » Publication #315536

Research Project: Genetic and Biological Determinants Of Respiratory Diseases Of Ruminants

Location: Genetics, Breeding, and Animal Health Research

Title: Full-length coding sequence for 12 bovine viral diarrhea virus isolates from persistently infected cattle in a feedyard in Kansas

Author
item Workman, Aspen
item Harhay, Gregory
item Heaton, Michael - Mike
item Grotelueschen, Dale - UNIVERSITY OF NEBRASKA
item Sjeklocha, David - CATTLE EMPIRE, LLC
item Smith, Timothy - Tim

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/17/2015
Publication Date: 5/21/2015
Citation: Workman, A.M., Harhay, G.P., Heaton, M.P., Grotelueschen, D.M., Sjeklocha, D.B., Smith, T.P.L. 2015. Full-length coding sequence for 12 bovine viral diarrhea virus isolates from persistently infected cattle in a feedyard in Kansas. Genome Announcements. 3(3):e00487-15. doi:10.1128/genomeA.00487-15.

Interpretive Summary: Bovine viral diarrhea virus (BVDV) is an important pathogen of cattle that has a substantial impact on animal health and well-being. BVDV infection can lead to respiratory disease, enteritis, immune dysfunction, and can predispose the animal to secondary infections. This study used next generation sequencing to determine the genome sequence of 12 BVDV isolates from persistently infected cattle from a Kansas feedyard. This study provides valuable information about the diversity of viral strains circulating in the U.S. and provides reference for studying viral evolution over time.

Technical Abstract: We report here the full-length coding sequence of 12 bovine viral diarrhea virus (BVDV) isolates from persistently infected cattle from a feedyard in southwest Kansas, USA. These 12 genomes represent the three major genotypes (BVDV 1a, 1b, and 2a) of BVDV currently circulating in the United States.