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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Infectious Bacterial Diseases Research » Research » Publications at this Location » Publication #311354

Title: Vaccination of cattle animals against tuberculosis

item VORDERMEIER, H - Veterinary Laboratories Agency (VLA)
item BUDDLE, BRYCE - Agresearch
item VILLARREAL-RAMOS, BERNARDO - Veterinary Laboratories Agency (VLA)
item JONES, GARETH - Veterinary Laboratories Agency (VLA)
item HEWINSON, R - Veterinary Laboratories Agency (VLA)
item Waters, Wade

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 12/19/2014
Publication Date: 9/28/2015
Citation: Vordermeier, H.M., Buddle, B.M., Villarreal-Ramos, B., Jones, G.J., Hewinson, R.G., Waters, W.R. 2015. Vaccination of cattle animals against tuberculosis. In: Mukundan, M., Chambers, M. Waters, R., Larsen, M., editors. Tuberculosis, Leprosy, and Mycobacterial Diseases of Man and Animals: The Many Hosts of Mycobacteria. Boston, MA: Centre for Agriculture and Biosciences International. p. 185-201.

Interpretive Summary:

Technical Abstract: Bovine TB (bTB), mainly caused by Mycobacterium bovis, is a significant economic burden to the agricultural industries worldwide. It has been estimated that 50 million cattle are infected with M. bovis worldwide resulting in around US $3 billion losses annually and this is despite attempts to control the disease. Development of new and improved cattle vaccines and diagnostic reagents for cattle as well as other domestic animal species and wildlife has therefore emerged as research areas that could contribute to improved disease control. However, a number of challenges need to be overcome, some scientific, others legal or regulatory. Thus, in countries operating test and slaughter control strategies, differential diagnostic tests are required, particularly when vaccination involves bacille Calmette-Guérin- (BCG) or attenuated M. bovis vaccines that will compromise the specificity of standard tuberculin-based diagnostic tools. This chapter will provide a concise review of the state-of-the-art in vaccine and DIVA (differentiate infected from vaccinated animals) test development.