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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #308400

Research Project: IDENTIFICATION OF DISEASE MECHANISMS AND CONTROL STRATEGIES FOR BACTERIAL RESPIRATORY PATHOGENS IN CATTLE

Location: Ruminant Diseases and Immunology Research

Title: Genome sequences of Mannheimia haemolytica serotype A1 strains D153 and D193 from bovine pneumonia

Author
item HAUGLUND, MELISSA - Boehringer Ingelheim Pharmaceuticals
item Tatum, Fred
item Bayles, Darrell
item MAHESWARAN, SAMUEL - University Of Minnesota
item Briggs, Robert - Bob

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/18/2013
Publication Date: 10/1/2013
Publication URL: http://handle.nal.usda.gov/10113/61222
Citation: Hauglund, M.J., Tatum, F.M., Bayles, D.O., Maheswaran, S.K., Briggs, R.E. 2013. Genome sequences of Mannheimia haemolytica serotype A1 strains D153 and D193 from bovine pneumonia. Genome Announcements. 1(5):e00848-13. DOI: 10.1128/genomeA.00848-13.

Interpretive Summary: Mannheimia haemolytica is a costly bacterial causative agent of pneumonia (shipping fever) in cattle. This bacterium responds to stress and concurrent respiratory viral infection by greatly elevated levels of infection in cattle nasal passages. Although serotypes 1, 2, and 6 are common in cattle nasal passages, only serotypes 1 and 6 so respond and that is likely why these latter serotypes predominate in pneumonic disease. Whole genome sequencing was conducted to define the differences between the serotypes. This report describes the genomes of two serotype 2 strains. Comparison of these with the genomes of serotypes 1 and 6 will allow scientists to focus on factors related to the stress response and potentially lead to improved disease intervention strategies.

Technical Abstract: Here we report two genomes, one complete and one draft, from virulent bovine strains of Mannheimia haemolytica(strains D171 and D35)serotype A2 recovered prior to the field usage of modern antimicrobial drugs.