Author
AINSLIE-WALDMAN, CHERYL - University Of Minnesota | |
YOUNG, LINDSAY - University Of Minnesota | |
CHEN, CHI - University Of Minnesota | |
KURZER, MINDY - University Of Minnesota | |
Raatz, Susan | |
CSALLANY, SAARI - University Of Minnesota |
Submitted to: Food and Nutrition Sciences
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 10/16/2016 Publication Date: 10/20/2016 Publication URL: http://handle.nal.usda.gov/10113/63304 Citation: Ainslie-Waldman, C.E., Young, L.R., Chen, C., Kurzer, M.S., Raatz, S.K., Csallany, S.A. 2016. Moderate consumption of Omega-3 fatty acids significantly increases in vivo lipid peroxidation in postmenopausal women. Food and Nutrition Sciences. 7:1099-1111. Interpretive Summary: Dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) are recommended by public health organizations to reduce the risk of disease. However, n-3 PUFA are susceptible to an increase in lipid peroxidation in the human body. As part of a crossover dietary intervention study of a diet (20% of energy from fat) with or without an additional 3% of energy from n-3 PUFA, we measured total in vivo lipid peroxidation in healthy postmenopausal women (n=15). Our results indicated that the diet with 3% of energy from n-3 PUFA significantly increased the urinary concentrations compounds produced via lipid compared to the diet with less than 1% of energy from n-3 PUFA. These results demonstrate that an increase in 3% of energy from dietary n-3 PUFA increases in vivo lipid peroxidation. Technical Abstract: Dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) are recommended by public health organizations to reduce the risk of disease. However, n-3 PUFA are susceptible to an increase in lipid peroxidation in the human body. As part of a crossover dietary intervention study of a diet (20% of energy from fat) with or without an additional 3% of energy from n-3 PUFA, we measured total in vivo lipid peroxidation in healthy postmenopausal women (n=15). Our results indicated that the diet with 3% of energy from n-3 PUFA significantly increased the urinary concentrations compounds produced via lipid compared to the diet with less than 1% of energy from n-3 PUFA. These results demonstrate that an increase in 3% of energy from dietary n-3 PUFA increases in vivo lipid peroxidation. |