|Huwe, Janice - Retired ARS Employee|
|Dearfield, Kerry - Food Safety Inspection Service (FSIS)|
|Johnston, John - Food Safety Inspection Service (FSIS)|
Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 3/28/2012
Publication Date: 8/19/2012
Citation: Lupton, S.J., Huwe, J.K., Smith, D.J., Dearfield, K., Johnston, J.J. 2012. Absorption and distribution of perfluorooctane sulfonate (PFOS) in beef cattle. 244th American Chemical Society National Meeting, August 19-23, 2012, Philadelphia, PA. p. 91.
Technical Abstract: Perfluorooctane sulfonate (PFOS) is an industrial chemical that is found in biosolids, and the application of these biosolids to pastures has raised concerns about human exposure through the accumulation of PFOS in edible tissues of these animals. The United States Department of Agriculture (USDA) has undertaken a study to determine the absorption and distribution of PFOS in beef. Two Angus steers were given single oral bolus doses containing PFOS at 0.1 mg/kg and four Angus heifers were given single bolus doses containing PFOS at 10 mg/kg. Plasma was collected from each animal prior to and at various intervals after dosing through 11 months. PFOS concentrations were determined by liquid chromatography-quadrupole time of flight mass spectrometry (LC-QToF). The average maximum concentrations of PFOS in plasma for the steers and heifers were 0.77 +/- 0.05 ug/mL and 65 +/- 12 ug/mL, respectively. Half-life determinations for the two PFOS levels administered will be done using plasma concentrations.