Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 2/26/2012
Publication Date: N/A
Interpretive Summary: N/A
Technical Abstract: The development of new, safe public health insecticides is critical to offset the reduction of insecticide products due to concerns over the negative impacts to the ecosystem. Through funding made possible by the Deployed War-Fighter Protection program, we are developing new insecticide candidates based on the premise that trifluoromethyl phenyl carboxamides will be potent against disease-spreading pests yet safe or have relatively low toxicity for humans and other animals. We have designed and synthesized a set of 20 trifluoromethyl phenyl carboxamides for initial screening. The screening consisted of toxicity assays with Ae. aegypti larvae and adults and repellency assessment by evaluation of the Minimum Effective Dosage (MED) using adult female Ae. aegypti and Anopheles albimanus. Two compounds after 24 h and six after 48 h, all para- and meta- substituted, produced 100% mortality against activity Ae. aegypti adults after 48 h. None of the ortho- substituted trifluoromethyl group showed toxicity. One ortho- substituted compound had a MED equal to DEET and another ortho- substituted was better against Ae. aegypti. Based upon these results, we plan to synthesize additional similarly structured compounds to better understand the basis of insecticidal activity and to lead us to develop further novel insecticides.