Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 3/25/2012
Publication Date: 6/20/2012
Citation: Brunelle, B.W., Bearson, S.M., Bearson, B.L. 2012. Tetracycline can induce the expression of invasion factors in multidrug-resistant Salmonella during early-log phase [abstract]. American Society for Microbiology General Meeting, June 16-19, 2012, San Francisco, California. Paper No. 1606.
Technical Abstract: The prevalence of multidrug-resistant (MDR) Salmonella continues to be an important health and safety concern in both humans and animals worldwide. Because the response of drug resistant bacteria exposed to antibiotics can affect a variety of cellular processes, such as motility, attachment, and invasion, we investigated the effect of tetracycline on isolates of MDR Salmonella enterica serovar Typhimurium. We tested several isolates from each of the more common definitive phage types of S. Typhimurium, including DT104, DT120, DT193, and DT208; each isolate was resistant to at least four different antibiotics, including tetracycline. Although Salmonella invasion does not typically occur until late-log during its growth phase, we found that tetracycline induced the expression of invasion factors during early-log growth in several isolates. These results indicate that the invasive capabilities of a subset MDR S. Typhimurium are enhanced in the presence of tetracycline.