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ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Obesity and Metabolism Research » Research » Publications at this Location » Publication #271183

Title: The micronutrient genomics project: a community-driven knowledge base for micronutrient research

item VAN OMMEN, B - Tno Quality Of Life
item EL-SOHEMY, A - University Of Toronto
item HESKETH, JOHN - Newcastle University
item KAPUT, JIM - Food And Drug Administration(FDA)
item FENECH, MICHAEL - Newcastle University
item EVELO, T - Commonwealth Scientific And Industrial Research Organisation (CSIRO)
item MCARDLE, HARRY - Rowett Research Institute
item BOUWMAN, JILDAU - Tno Quality Of Life
item LIETZ, GEORGE - Newcastle University
item MATHERS, JOHN - Newcastle University
item FAIRWEATHER-TAIT, SUE - University Of East Anglia
item VAN KRANEN, HENK - National Institute For Public Health And The Environment (RIVM)
item ELLIOTT, RUAN - Institute Of Food Research - United Kingdom
item WOPEREIS, SUZAN - Tno Quality Of Life
item FERGUSON, LYNNETTE - University Of Auckland
item MEPLAN, CATHERINE - Newcastle University
item PEROZZI, GIUDITTA - National Research Institute For Food And Nutrition (INRAN)
item Allen, Lindsay - A

Submitted to: Genes and Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/13/2010
Publication Date: 10/30/2010
Citation: Van Ommen, B., El-Sohemy, A., Hesketh, J., Kaput, J., Fenech, M., Evelo, T., Mcardle, H.J., Bouwman, J., Lietz, G., Mathers, J.C., Fairweather-Tait, S., Van Kranen, H., Elliott, R., Wopereis, S., Ferguson, L.R., Meplan, C., Perozzi, G., Allen, L.H. 2010. The micronutrient genomics project: a community-driven knowledge base for micronutrient research. . 5(4):285-296.

Interpretive Summary:

Technical Abstract: Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, for maintaining good health. With advances in systems biology and genomics technologies, it is becoming feasible to assess the activity of single and multiple micronutrients in their complete biological context. Existing research collects fragments of information, which are not stored systematically and are thus not optimally disseminated. The Micronutrient Genomics Project (MGP) was established as a community-driven project to facilitate the development of systematic capture, storage, management, analyses, and dissemination of data and knowledge generated by biological studies focused on micronutrient-genome interactions. Specifically, the MGP creates a public portal and open-source bioinformatics toolbox for all "omics" information and evaluation of micronutrient and health studies. The core of the project focuses on access to, and visualization of, genetic/genomic, transcriptomic, proteomic and metabolomic information related to micronutrients. For each micronutrient, an expert group is or will be established combining the various relevant areas (including genetics, nutrition, biochemistry, and epidemiology). Each expert group will (1) collect all available knowledge, (2) collaborate with bioinformatics teams towards constructing the pathways and biological networks, and (3) publish their findings on a regular basis. The project is coordinated in a transparent manner, regular meetings are organized and dissemination is arranged through tools, a toolbox web portal, a communications website and dedicated publications.