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ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Obesity and Metabolism Research » Research » Publications at this Location » Publication #271183

Research Project: Mineral and Vitamin Interventions for At-risk Populations

Location: Obesity and Metabolism Research

Title: The micronutrient genomics project: a community-driven knowledge base for micronutrient research

item Van Ommen, B
item El-sohemy, A
item Hesketh, John
item Kaput, Jim
item Fenech, Michael
item Evelo, T
item Mcardle, Harry
item Bouwman, Jildau
item Lietz, George
item Mathers, John
item Fairweather-tait, Sue
item Van Kranen, Henk
item Elliott, Ruan
item Wopereis, Suzan
item Ferguson, Lynnette
item Meplan, Catherine
item Perozzi, Giuditta
item Allen, Lindsay

Submitted to: Genes and Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/13/2010
Publication Date: 10/30/2010
Publication URL:
Citation: Van Ommen, B., El-Sohemy, A., Hesketh, J., Kaput, J., Fenech, M., Evelo, T., Mcardle, H.J., Bouwman, J., Lietz, G., Mathers, J.C., Fairweather-Tait, S., Van Kranen, H., Elliott, R., Wopereis, S., Ferguson, L.R., Meplan, C., Perozzi, G., Allen, L.H. 2010. The micronutrient genomics project: a community-driven knowledge base for micronutrient research. . 5(4):285-296.

Interpretive Summary:

Technical Abstract: Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, for maintaining good health. With advances in systems biology and genomics technologies, it is becoming feasible to assess the activity of single and multiple micronutrients in their complete biological context. Existing research collects fragments of information, which are not stored systematically and are thus not optimally disseminated. The Micronutrient Genomics Project (MGP) was established as a community-driven project to facilitate the development of systematic capture, storage, management, analyses, and dissemination of data and knowledge generated by biological studies focused on micronutrient-genome interactions. Specifically, the MGP creates a public portal and open-source bioinformatics toolbox for all "omics" information and evaluation of micronutrient and health studies. The core of the project focuses on access to, and visualization of, genetic/genomic, transcriptomic, proteomic and metabolomic information related to micronutrients. For each micronutrient, an expert group is or will be established combining the various relevant areas (including genetics, nutrition, biochemistry, and epidemiology). Each expert group will (1) collect all available knowledge, (2) collaborate with bioinformatics teams towards constructing the pathways and biological networks, and (3) publish their findings on a regular basis. The project is coordinated in a transparent manner, regular meetings are organized and dissemination is arranged through tools, a toolbox web portal, a communications website and dedicated publications.