Submitted to: Plant and Animal Genome Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 11/9/2010
Publication Date: 1/15/2011
Citation: Casas, E., Garcia, M.D., Wells, J., Smith, T.P. 2011. Association of single nucleotide polymorphisms in the ANKRA2 and CD180 genes with bovine respiratory disease and presence of Mycobacterium avium subsp. paratuberculosis [abstract]. Plant and Animal Genome XIX Conference. Poster No. P193. Interpretive Summary:
Technical Abstract: The objective was to determine if single nucleotide polymorphisms (SNPs) in the ANKRA2 and CD180 genes were associated with incidence of bovine respiratory disease (BRD) and presence of Mycobacterium avium subsp. paratuberculosis (MAP) in cattle. Two independent populations were used. The first population (BRD-affected; N = 90) was composed of 31 half-sib progeny from a Brahman x Angus sire that were treated for BRD. Untreated offspring from the sire were selected to serve as controls. The second population (MAP-infected), of 330 animals of unknown parentage were evaluated for the presence of MAP in ileocecal lymph node and classified as positive or negative. Markers in both genes were assessed for association in these two populations. In the BRD-affected population, five SNP in the ANKRA2 gene were significantly associated (P < 0.05), and two SNP were highly associated (P < 0.01) with incidence of BRD. In addition, two SNP in the CD180 were found to be associated with this trait. In the MAP-infected population, one SNP in the ANKRA2 gene was significantly associated (P < 0.05) with presence or absence of MAP and an SNP in the CD180 gene was highly associated (P < 0.01) with the trait. Haplotypes, using significant markers, showed a positive association with both, incidence of BRD (P = 0.0001) and with presence of MAP (P = 0.0032). Markers in the ANKRA2 and CD180 genes are associated with the ability of the animal to cope with pathogens.