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United States Department of Agriculture

Agricultural Research Service

Research Project: Linking Foods, Behavior and Metabolism to Promote a Healthy Body Weight

Location: Obesity and Metabolism Research

Title: The human serum metabolome)

Author
item Psychogios, Nikolaos
item Hau, David
item Peng, Jun
item Guo, An chi
item Mandal, Ruparsi
item Bouatra, Souhaila
item Sinelnikov, Igor
item Krishnamurthy, Ramanarayan
item Eisner, Roman
item Gautam, Bijaya
item Young, Nelson
item Xia, Jinaguo
item Knox, Craig
item Dong, Edison
item Huang, Paul
item Hollander, Zsuzsanna
item Pedersen, Theresa
item Smith, Steven
item Bamforth, Fiona
item Greiner, Russ
item Mcmanus, Bruce
item Newman, John
item Goodfriend, Theodore
item Wishart, David

Submitted to: PLoS One
Publication Type: Peer reviewed journal
Publication Acceptance Date: 1/18/2011
Publication Date: 2/16/2011
Publication URL: www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0016957
Citation: Psychogios, N., Hau, D.D., Peng, J., Guo, A., Mandal, R., Bouatra, S., Sinelnikov, I., Krishnamurthy, R., Eisner, R., Gautam, B., Young, N., Xia, J., Knox, C., Dong, E., Huang, P., Hollander, Z., Pedersen, T.L., Smith, S.R., Bamforth, F., Greiner, R., Mcmanus, B., Newman, J.W., Goodfriend, T., Wishart, D.S. 2011. THE HUMAN SERUM METABOLOME. PLoS One. 6(2): e16957.

Interpretive Summary: Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today‘s technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca.

Technical Abstract: Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today‘s technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca.

Last Modified: 8/24/2016
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