|DEEGAN, KATHLEEN - California State University|
|RAMIREZ-ZEA, MANUEL - Instituto Biologicio - Brazil|
|ZULETA, CLARA - Instituto Biologicio - Brazil|
|LILDBALLE, DORTE - Aarhus University|
|NEXO, EBBA - Aarhus University|
|Allen, Lindsay - A|
Submitted to: European Journal of Clinical Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/11/2010
Publication Date: N/A
Interpretive Summary: High dose vitamin B-12 supplements (=750 µg/day) did improve maternal status and increase milk B-12 concentration in a sample of women, this is not an effective or efficient method for improving infant vitamin B-12 status. Given the potential adverse effects of vitamin B-12 deficiency on infant development there is need for a more effective approach. Since maternal vitamin B-12 status is also of concern, and both maternal and infant vitamin B-12 deficiency and depletion are common in populations consuming low intakes of ASF, policies such as vitamin B-12 fortification of flour, or maternal supplementation prior to conception and during pregnancy, should be evaluated for their effectiveness.
Technical Abstract: Vitamin B-12 deficiency is common in mothers and infants where maternal intake of animals source foods is low. The first six months post-partum is a critical period of neurological development requiring vitamin B-12. A pilot study was designed to determine the dose of B-12 to the mothers that would normalize infant B-12 status in vitamin B-12 depleted lactating women and their infants in Guatemala. Women were screened for marginal serum B-12 status (150-220 pmol/L), then randomized to one of six doses (rang 3 to 1000 µg/d) for two months. After one month, a dose response was observed in maternal serum B-12 (r=0.77, P<0.001) and milk B-12 (r=0.78, P<0.001), but not in infant serum B-12 (r=0.15, P<0.001) or infant UMMA (r=-0.13, P<0.33). After 2 months the significant dose response in maternal serum and milk B-12 concentrations persisted, but no supplementation level produced normal B-12 status in all infants (serum B-12 <250 pmol/L).