|Nielsen, Forrest - Frosty|
Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 12/15/2009
Publication Date: 4/24/2010
Publication URL: www.fasebj.org
Citation: Nielsen, F.H., Johnson, L.K. 2010. Magnesium (Mg) Supplementation Improves Magnesium Status And Decreases Elevated C-reactive Protein in Adults Older Than 51 Years With Poor Quality Sleep.. Journal of Federation of American Societies for Experimental Biology. 24:325.8. Interpretive Summary:
Technical Abstract: NHANES data indicate that two-thirds of U.S. adults consume less than the RDA for Mg. A low Mg intake or status has been associated with poor quality sleep and inflammatory stress. Thus, 100 adults (22 males and 78 females) older than 51 yr with a Pittsburgh Sleep Quality Index (PSQI) higher than 5 were randomly assigned to 2 groups matched by gender, age, and overall PSQI score. After baseline assessment (wk 1), one group was given a 300 mg/d Mg supplement as Mg citrate, and the other a sodium citrate placebo, for 7 wk. Final assessments were made 5 and 7 wk after supplement initiation for 96 subjects that completed the study as designed.PSQI improved (10.4 to 6.6, p<0.0001) and erythrocyte Mg increased (4.75 to 5.05 pg/cell) regardless of Mg or placebo supplementation. The erythrocyte Mg increase was ~70% greater with Mg supplementation (4.72 to 5.15 vs. 4.78 to 4.94 pg/cell). Mg supplementation reduced plasma C-reactive protein in subjects with baseline values >3.0 mg/dL; these subjects also had a higher body mass index. Baseline serum Mg was below normal (<1.8 mg/dL) in 37 subjects. Analysis of these subjects found that serum Mg and calcium (Ca) were significantly increased with the increases more marked with Mg-supplementation (Ca, 8.36 to 8.74 vs. 8.43 to 8.52 mg/dL; Mg 1.69 to 1.82 vs. 1.69 to 1.73 mg/dL). Findings indicate that Mg status of many older individuals could be improved.