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United States Department of Agriculture

Agricultural Research Service

Research Project: HOST IMMUNOGENETICS PREDICT CLINICAL DISEASES IN OVINE PROGRESSIVE PNEUMONIA VIRUS INFECTED SHEEP

Location: Animal Disease Research

Title: The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution)

Author
item Elsik, Christine
item Gibbs, Richard
item Skow, Loren
item Tellam, Ross
item Weinstock, George
item Worley, Kimberly
item Kappes, Steven - Steve
item Green, Ronald
item Alexander, Leeson
item Bennett, Gary
item Carroll, Jeffery - Jeff carroll
item Chitko mckown, Carol
item Hamernik, Debora
item Harhay, Gregory
item Keele, John
item Liu, Ge - George
item Macneil, Michael
item Matukumalli, Lakshmi
item Rijnkels, Monique
item Roberts, Andrew - Andy
item Smith, Timothy - Tim
item Snelling, Warren
item Stone, Roger
item Waterman, Richard
item White, Stephen
item Sonstegard, Tad
item Van tassell, Curtis - Curt

Submitted to: Science
Publication Type: Peer reviewed journal
Publication Acceptance Date: 3/16/2009
Publication Date: 4/24/2009
Publication URL: www.sciencemag.org/cgi/reprint/324/5926/522.pdf
Citation: Elsik, C.G., Gibbs, R., Skow, L., Tellam, R., Weinstock, G., Worley, K., Kappes, S.M., Green, R.D., Alexander, L.J., Bennett, G.L., Carroll, J.A., Chitko Mckown, C.G., Hamernik, D.L., Harhay, G.P., Keele, J.W., Liu, G., Macneil, M.D., Matukumalli, L.K., Rijnkels, M., Roberts, A.J., Smith, T.P., Snelling, W.M., Stone, R.T., Waterman, R.C., White, S.N. 2009. The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. Science. 324:522-528.

Interpretive Summary: As a major step toward understanding the biology and evolution of ruminants, the cattle genome was sequenced to ~7x coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 identifiable equivalents found in seven mammalian species. There are many evolutionary breakpoint regions in chromosomes identified by cross-species analysis, but those that are cattle-specific have a higher density of chromosome segment duplications, several types of repetitive elements, and species-specific variants in genes associated with lactation and immune responsiveness. Genes involved in metabolism were found highly conserved, although five metabolic genes are deleted or extensively diverged from their human counterparts. The cattle genome sequence provides a new resource for mammalian genome annotation and for accelerating genetic improvement for milk and meat production.

Technical Abstract: As a major step toward understanding the biology and evolution of ruminants, the cattle genome was sequenced to ~7x coverage using a combined whole genome shotgun and BAC skim approach. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs found in seven mammalian species. Evolutionary breakpoint regions in chromosomes that are cattle-specific have a higher density of segmental duplications, several types of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism were found highly conserved, although five metabolic genes are deleted or extensively diverged from their human counterparts. The cattle genome sequence provides a new resource for mammalian genome annotation and for accelerating genetic improvement for milk and meat production.

Last Modified: 8/24/2016
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