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ARS Home » Pacific West Area » Pullman, Washington » Animal Disease Research » Research » Publications at this Location » Publication #228150
Title: Biotechnology in the diagnosis of infectious diseases and vaccine development

Author
item Knowles Jr, Donald
item Li, Hong
item PASTORET, P - INST FOR ANIMAL HEALTH UK

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 1/14/2008
Publication Date: 10/1/2008
Citation: Knowles Jr, D.P., Li, H., Pastoret, P.P. 2008. Biotechnology in the diagnosis of infectious diseases and vaccine development. In: Pearson, J.E. Manual of Standards for Diagnostic Tests and Vaccines for Terrestrial Animals. Paris, France. Office des International des Epizooites. 66-89.

Interpretive Summary: This is the updated version of the chapter "Biotechnology in the diagnosis of infectious diseases and vaccine development" in the 6th edition of Manual of diagnostic Tests and Vaccines for Terrestrial Animals by OIE. As molecular biological methods have become increasingly applicable to the diagnosis of infectious diseases and vaccine development, the purpose of this chapter is to provide general information for the nonspecialists about current biotechnology in the diagnosis of infectious disease and vaccine development. The topics briefly reviewed in the chapter include the common diagnostic assays for detection of nucleic acids, proteins and antibodies, as well as development in vaccine technology.

Technical Abstract: Molecular biological methods have become increasingly applicable to the diagnosis of infectious diseases and vaccine development. To become widely used the methods need to be easy, safe, sensitive, reproducible and eventually automated to facilitate the evaluation of large number of samples. The purpose of this chapter is to provide general background information for the nonspecialists about current biotechnology in the diagnosis of infectious disease and vaccine development. The topics briefly reviewed in the chapter include the common diagnostic assays for detection of nucleic acids, proteins and antibodies, as well as the development in vaccine technology.