Submitted to: JOM: The Member Journal of TMS
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/1/2008
Publication Date: 4/1/2008
Citation: Karakoti, A.S., Monteiro-Riviere, N.A., Aggarwal, R., Davis, J.P., Narayan, R.J., Self, W.T., Mcginnis, J., Seal, S. 2008. Nanoceria as Antioxidant: Synthesis and Biomedical Applications. JOM: The Member Journal of TMS 60:(3) 33-37. Interpretive Summary: Cerium oxide nanoparticles exhibit unique capabilities for quenching free radicals. In this paper, the synthesis and biological properties of these materials were examined. These materials could find widespread use in the treatment of free radical mediated medical disorders.
Technical Abstract: The therapeutic application of nanomaterials has been a focus of numerous studies in the past decade. Due to its unique redox properties, cerium oxide (ceria) is finding widespread use in the treatment of medical disorders caused by the reactive oxygen intermediates (ROI). The radical-scavenging role of ceria nanoparticles (nanoceria) have been established, as well as the autocatalytic ability of nanoceria to regenerate under various environmental conditions. The synthesis of nanoceria in biocompatible media has also been reported along with cell viability in order to determine the potential use of nanoceria in biomedical applications.