|Nielsen, Forrest - Frosty|
Submitted to: Meeting Abstract
Publication Type: Abstract only
Publication Acceptance Date: 9/1/2006
Publication Date: 12/5/2006
Publication URL: www.elsevier.com/locate/bone
Citation: Steimetz, T., Katok, K., Gorustovich, A., Krieger, M.L., Nielsen, F.H., Guglielmotti, M.B. 2006. Bone remodeling and silicon deficiency in rats [abstract]. Bone. 40:S8. Interpretive Summary:
Technical Abstract: Alveolar bone undergoes continuous remodeling to meet physiologic and functional demands. The aim of the present work was to evaluate histologically and histomorphometrically the effect of silicon deficiency on bone modeling and remodeling in the periodontal cortical plate. Two groups of weaning male Wistar rats (aged 21 days) were used: Control Group (CG n=10) fed a basal diet supplemented with 35 mg Si/kg diet; Experimental Group (EG n=8) fed a silicon-deficient diet (2 mg Si/Kg diet). All the rats were euthanized at 30 days. The mandibles were resected, fixed, radiographed, processed, and embedded in paraffin. Buccolingually oriented sections at the level of the mesial root of the first molar were obtained, and stained with H&E. The following parameters were measured: percentage of osteoblast (ObS), quiescent (QS) and eroded (ES) bone surfaces. Histology: EG rats showed a decrease in ObS in both cortical plates, an increase in ES in the buccal cortical plate and in QS in the lingual cortical plate. Histomorphometry: EG rats showed a decrease in ObS. (GC=45%, GE=30%) (p<0.001) concomitant with an increase in ES. (GC=16%, GE=28%) (p<0.005), and no significant differences in QS (GC=39%, GE=42%) in the buccal cortical plates, and a decrease in ObS (GC=62%, GE=48%) (p<0.0001) concomitant with an increase in QS (GC=38%, GE=52%) (p<0.0001) in the lingual cortical plate. Our findings show the importance of an adequate supply of silicon for bone remodeling, especially for bone formation. UBACYT 020, CONICET PIP 6042, USDA 58-5450-3-F094.