Submitted to: International Workshop on Brominated Flame Retardants
Publication Type: Abstract Only
Publication Acceptance Date: 12/10/2006
Publication Date: 4/24/2007
Citation: Hakk, H., Huwe, J.K., Larsen, G.L. 2007. An ADME study with 2,2'4,4',-tetrabromodiphenyl ether (BDE-47) in chickens. Meeting Abstract. BFR 2007 4th International Workshop on Brominated Flame Retardants, April 24-27, 2007, Amsterdam, The Netherlands. Interpretive Summary:
Technical Abstract: Studies in mammals have shown that lipophilic tissues such as adipose and skin are major depots for persistent polybrominated diphenyl ethers (PBDE’s). Since humans commonly consume the skin of a chicken, it was of interest to conduct an adsorption, tissue disposition, metabolism and excretion study in this production avian species with the most persistent PBDE found in biota, i.e. 2,2',4,4'-tetrabromodiphenyl ether (BDE-47). Results demonstrated that, as previously shown in rats and mice, BDE-47 was well absorbed (61% in tissues at 72h), and was distributed both on a % dose basis and a concentration basis to lipophilic tissues, i.e. adipose tissue, skin and GI tract. Metabolism to free metabolites was less than 1% of the dose, although non-extractable urine/feces metabolites accounted for about 12% of the dose. Free metabolites were characterized as being hydroxylated and debrominated. Absorption, tissue distribution and metabolism of BDE-47 in chickens was very similar to that observed in rats and mice, in that adipose tissue and skin remain primary depots for this persistent PBDE.