Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 12/2/2002
Publication Date: 3/14/2003
Citation: Yokoi, K., Egger, N.G., Ramanujam, V.M.S., Alcock, N.W., Dayal, H.H., Penland, J.G., Sandstead, H.H. 2003. Associations between iron and zinc nutriture in premenopausal women [abstract]. Federation of American Societies for Experimental Biology Journal. 17:A302.
Technical Abstract: Iron (Fe) and zinc (Zn) are available from similar foods. To define associations of Fe and Zn nutriture, Fe and Zn indicators including Zn kinetics were measured in 50 healthy premenopausal women. In 30 subjects with plasma Zn >/- 700 ug/L, serum ferritin (SF), serum Fe, and percent saturation of Fe binding proteins were higher (p<0.03) than in low Zn subjects. Food frequency correlated with SF and Zn kinetics in 33 subjects not on oral contraceptives. Beef was the positive predictor of SF (p=0.002); bran cereal (p=0.097) and bleeding through pads (BTP) (p=0.021) were negative predictors (n=32, R**2=0.326, p=0.010). Beef positively predicted (p=0.003) and BTP negatively predicted (p=0.010) the rapidly exchangeable Zn pool/fat free mass (FFM) (n=31, R**2 = 0.322, p = 0.004). SF correlated with the central Zn pool (Q**1, the plasma) / FFM (n=31, R**2=0.394, p<0.0001), the lesser peripheral Zn pool (Q**2) / FFM (broken line equation, n=27, R**2=0.756, p<0.0001), and the greater peripheral Zn pool (Q**3) / FFM (n=32, R**2=0.167, p=0.020). In the broken line model, the breakpoint for Q**2 was at SF 17.8 ug/L; below the breakpoint, Q**2 tended not to decrease; above the breakpoint, Q**2 increased proportionate to SF. In conclusion, 1) Fe and Zn status are highly related; 2) Food frequency correlated with Fe and Zn status; 3) Zn deficiency was associated with SF<20 ug/L. Support: DAMD 17-95-C-5112 & USPHS M01-RR-00073.