Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract only
Publication Acceptance Date: 12/2/2002
Publication Date: 3/14/2003
Citation: Lukaski, H.C., Hall, C.B., Michelsen, K.G. 2003. Effects of dietary zinc and exercise training on zinc status and carbonic anhydrase activities. The Federation of American Societies for Experimental Biology Journal. 17:A695. Interpretive Summary:
Technical Abstract: Zinc (Zn) has been postulated to affect physical performance by influencing the activities of Zn-containing enzymes. We examined the interaction of dietary Zn and exercise training on Zn status and carbonic anhydrase (CA) isoenzyme activities by using a 2 x 4 factorial experiment. Sixty-four weanling male Sprague-Dawley rats were matched by weight, assigned to four groups and fed graded dietary Zn: adequate (15 mg/kg), marginal (5 mg/kg), pair-fed (15 mg/kg), and supplemental (30 mg/kg). Within each group, rats were randomized to non-exercise and progressive endurance treadmill running (5d/wk) for 12 wk. Exercise decreased (p<0.001) body weight and increased (p<0.0001) citrate synthase activity in soleus muscle. Marginal Zn decreased (p<0.01) red blood cell (RBC) and femur Zn concentrations; exercise training increased (p<0.01) femur Zn concentration. Neither dietary Zn nor exercise affected hemoglobin or plasma Zn concentrations. Endurance training increased (p<0.01) RBC CA-I and CA-II activities; marginal Zn decreased (p<0.01) RBC CA-II activity. Treadmill running increased (p<0.01) muscle CA-III activity; marginal Zn decreased (p<0.01) muscle CA-III activity. These findings indicate that restricted dietary Zn intake decreases CA isoenzyme activities and may impair physical performance by adversely affecting cardiorespiratory function.