Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract only
Publication Acceptance Date: 12/2/2002
Publication Date: 3/14/2003
Citation: Nielsen, F.H. 2003. Boron deficiency alters platelet aggregation differently than replacing palm oil with canola oil in the diet of rats [abstract]. The Federation of American Societies for Experimental Biology Journal. 17:A707. Interpretive Summary:
Technical Abstract: Support for the hypothesis that both boron (B) and long-chain n-3 fatty acids have membrane functions that affect each other would be finding that changes in B and n-3 fatty acid intakes affect a membrane-involved process such as platelet aggregation. Thus, female and male adult rats were fed diets containing about 70 ug B/kg in a factorial arrangement with supplemental B at 0 (deficient) and 3 (adequate) mg/kg and canola oil (CO, high in n-3 fatty acids) or palm (PO, low in n-3 fatty acids) at 75 g/kg of diet as variables. After 5 weeks, 6 females per treatment were bred. Dams and pups continued on their respective dietary treatments through gestation, lactation and after weaning. In non-fasting female pups (7 to 9 per treatment) at 17 weeks after weaning, replacing PO with CO increased mean platelet volume (P<0.03) but decreased platelet number (P<0.003) and ATP release induced by collagen (P<0.01) and thrombin (P<0.01); B deficiency did not significantly affect these variables. Platelet aggregation induced by collagen was increased (P<0.002) and induced by ADP was decreased (P<0.05) by B deficiency. Replacing PO with CO tended to increase aggregation induced by ADP (P<0.06). Although dietary oil and B did not interact to affect platelet aggregation, the findings support the hypothesis that B and n-3 fatty acids affect similar systems in higher animals, possibly through altering membrane function.