Skip to main content
ARS Home » Plains Area » Grand Forks, North Dakota » Grand Forks Human Nutrition Research Center » Healthy Body Weight Research » Research » Publications at this Location » Publication #135863
Title: INFLAMMATORY POLYARTHRITIS IN COLLAGEN-INDUCED ARTHRITIS IS SIGNIFICANTLY REDUCED BY PHYSIOLOGICAL AMOUNTS OF DIETARY BORON

Author
item DURICK, KELLY - UNIV OF NORTH DAKOTA
item LAMOUREUX, JENNIFER - UNIV OF NORTH DAKOTA
item O'BRYANT, DEANNA - UNIV OF NORTH DAKOTA
item GRIFFITHS, MARIE - UNIV OF UTAH
item Hunt, Curtiss
item BRADLEY, DAVID - UNIV OF NORTH DAKOTA

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 4/18/2003
Publication Date: 4/24/2003
Citation: Durick, K., Lamoureux, J., O'Bryant, D., Griffiths, M.M., Hunt, C.D., Bradley, D.S. 2002. Inflammatory polyarthritis in collagen-induced arthritis is significantly reduced by physiological amounts of dietary boron [abstract]. Presented by K. Durick at Frank Low Research Day, University of North Dakota, Grand Forks, ND. April 24, 2002.

Interpretive Summary:

Technical Abstract: We have previously shown physiological amounts of boron repress the inflammatory events in adjuvant-induced arthritis in rats. It has been hypothesized that the boron-induced regulation may occur via reduction of leukocyte-produced reactive oxygen species. We present here evidence of an anti-inflammatory influence of boron on collagen-induced arthritis (CIA), an animal model of human rheumatoid arthritis (RA). Mice were weaned into three experimental groups receiving one of the following diets: boron deficient (~0.04 mg/kg boron), boron-adequate (2.0 mg/kg boron), and normal rodent chow (12.0 mg/kg boron; however, this boron is apparently complexed such that it is not accessible for absorption during digestion). Each experimental group was immunized with type II collagen (CII) and observed for clinical disease. Mice fed the boron-adequate diet were resistant to CIA (~10% incidence), compared to mice receiving boron-deficient and normal rodent chow, 60% and 72% incidence, respectively. The few boron-adequate animals that did develop polyarthritis displayed an 11 day delay in disease onset, compared to the groups maintained on either boron-deficient and normal rodent chow, and the polyarthritis that developed was also much less severe in the boron-adequate group as well. The influence of boron on established polyarthritis is currently being evaluated and these results will also be presented. These findings suggest that boron may provide an excellent alternative therapy to regulate inflammatory diseases, such as RA.