Submitted to: Canadian Association of Laboratory Animal Science
Publication Type: Abstract Only
Publication Acceptance Date: 3/28/2000
Publication Date: 5/1/2000
Citation: Finley, J.W., Gregoire, B.R., Davis, C.D., Hintze, K.J. 2000. Selenium from high-selenium broccoli is protective against colon cancer [abstract]. Presented at the Canadian Association of Laboratory Animal Science, Winnipeg, Manitoba, Canada.
Technical Abstract: Selenium (Se)supplementation might prevent colon cancer in humans. The metabolism of Se depends on its chemical form; Se in broccoli does not accumulate in the body as fast as other forms of Se, and might be especially beneficial for prevention of cancer. Fisher F-344 rats were fed adequate (0.1 ug Se/g diet) or supranutritional amounts of Se (1.0 or 2.0 ug Se/g diet) provided as selenate, selenite or high-Se broccoli, and colon cancer was induced by injecting the rats with 3,2 dimethyl 4-amino biphenyl or dimethyl-hydrazine. Supranutritional amounts of Se from high- Se broccoli decreased (P<0.05) the incidence of aberrant crypts (AC) and aberrant crypt foci (ACF; lesions indicative of colon cancer) more than other dietary treatments. The same reduction did not occur with broccoli alone or Se alone. Adequate dietary Se supplied as high-Se broccoli did not accumulate in tissues or increase glutathione peroxidase activity as well as other forms and amounts of Se. Thus, Se from high-Se broccoli may be metabolized in a manner that diverts much of the Se into a pool that provides increased protection against colon cancer.