Submitted to: Great Lakes Regional American Chemical Society Symposium
Publication Type: Abstract only
Publication Acceptance Date: 3/6/2000
Publication Date: 4/1/2000
Citation: Gregoire, B.R., Finley, J.W., Davis, C.D., Hintze, K.J. 2000. Selenium from high-selenium broccoli is protective against colon cancer [abstract]. Presented at the Great Lakes Regional American Chemical Society Symposium, Fargo, ND. Interpretive Summary:
Technical Abstract: Selenium (Se) supplementation may prevent colon cancer in humans. The metabolism of Se depends on its chemical form; Se in broccoli does not accumulate in the body as fast as other forms of Se, and may be especially beneficial for prevention of cancer. Fisher F-344 rats were fed adequate (0.1 ug Se/g diet) or supranutritional amounts of Se (1.0 or 2.0 ug Se/g diet) provided as selenate, selenite or high-Se broccoli, and colon cancer was induced by injecting the rats with 3,2 dimethyl 4-amino biphenyl or dimethyl-hydrazine. Supranutritional amounts of Se from high-Se broccoli decreased (P<0.05) the incidence of aberrant crypts (AC) and aberrant crypt foci (ACF; lesions indicative of colon cancer) more than other dietary treatments. The same reduction did not occur with broccoli alone or Se alone. Adequate dietary Se supplied as high-Se broccoli did not accumulate in tissues or increase glutathione peroxidase activity as well as other forms and amounts of Se. Thus, Se from high-Se broccoli may be metabolized in a manner that diverts much of the Se into a pool that provides increased protection against colon cancer.