Location: Microbiome and Metabolism Research
Project Number: 6026-51000-012-020-S
Project Type: Non-Assistance Cooperative Agreement
Start Date: Aug 1, 2023
End Date: Jul 31, 2028
To determine the role of prenatal and early-life dietary factors and the gut microbiota on host health. The overarching goals of the current project are: 1) to determine the mechanism of how prenatal factors and early diet affect the development and function of key physiological systems (e.g., metabolism, gut physiology, liver, lungs, brain, kidney, and immune system), 2) to understand host-gut microbiota cross-talk, and 3) to unveil immunomodulatory functions of milk bioactives with and without microbiota. Ultimately, the goal is to investigate prenatal factors such as the impact of maternal obesity on mothers’ immune system and to determine the role of infant diet (i.e human milk or formula) on a child’s health.
To achieve these objectives, extensively detailed research plans have been developed, reviewed and approved that encompasses the specific research described below. Research is to be accomplished over a multi-year period as resources are available and as readiness for research and management capabilities develop. These plans address the following research areas and other research studies mutually agreed upon and approved by the Office of Scientific Quality Review: ARS Unit Objectives: Objective 1: Determine the role of prenatal factors on mother’s health. Objective 2: Investigate the role of prenatal factors and postnatal factors on infants’ health.