Research Project: Host-pathogen Interactions and Control Strategies for Bacterial Respiratory Pathogens in Cattle

Location: Ruminant Diseases and Immunology Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Transcriptome profiling indicates varied gene responses to Pasteurella multocida mutant infections in cattle - (Peer Reviewed Journal)
Ma, H., Tatum, F.M., Briggs, R.E., Dassanayake, R.P., Kendrick, T.M., Casas, E. 2026. Transcriptome profiling indicates varied gene responses to Pasteurella multocida mutant infections in cattle. PLOS ONE. 21(1). Article e0341813. https://doi.org/10.1371/journal.pone.0341813.

Evaluation of a P48 ELISA for Mycoplasma bovis in North American bison (Bison bison): inferior performance compared to a commercially available ELISA - (Peer Reviewed Journal)

Maintenance of sub clinical Mycoplasma bovis infections in American bison (Bison bison) in the absence of detectable transmission - (Peer Reviewed Journal)

Mycoplasma bovis in North American bison (Bison bison): history, advances, and challenges - (Review Article)
Buttke, D.E., Kaplan, B.S., Bragg, T.K., Jones, L.C., Malmberg, J.L. 2026. Mycoplasma bovis in North American bison: history, advances, and challenges. Frontiers in Ecology and Evolution. 13. Article 1689117. https://doi.org/10.3389/fevo.2025.1689117.

Mycoplasma leachii strain PG50 shows reduced adherence and invasion compared to M. bovis strains 428E and PG45 - (Peer Reviewed Journal)
Nielsen, D.W., Hau, S.J., Holthausen, D.J., Dassanayake, R.P., Kaplan, B.S. 2025. Mycoplasma leachii strain PG50 shows reduced adherence and invasion compared to M. bovis strains 428E and PG45. Veterinary Research Communications. 49. Article 339. https://doi.org/10.1007/s11259-025-10901-x.

Transcriptional profiles of vaccine-induced protection in bovine herpesvirus-1 and mycoplasma bovis-challenged bison - (Peer Reviewed Journal)
Goldkamp, A.K., Kaplan, B.S., Menghwar, H., Kanipe, C.R., Boggiatto, P.M., Crawford, L.S., Olsen, S.C., Briggs, R.E., Tatum, F.M., Dassanayake, R.P., Casas, E. 2025. Transcriptional profiles of vaccine-induced protection in bovine herpesvirus-1 and mycoplasma bovis-challenged bison. Frontiers in Veterinary Science. 12. Article 1667623. https://doi.org/10.3389/fvets.2025.1667623.

A modified-live Mannheimia haemolytica expressing Mycoplasma bovis EFTu and Hsp70 induced systemic and mucosal antibody responses in American bison but failed to fully protect against Mycoplasma bovis challenge - (Peer Reviewed Journal)
Kaplan, B.S., Dassanayake, R.P., Chriswell, B.O., Boatwright Jr, W.D., Olsen, S.C., Palmer, M.V., Boggiatto, P.M., Kanipe, C.R., Casas, E., Briggs, R.E., Tatum, F.M. 2025. A modified-live Mannheimia haemolytica expressing Mycoplasma bovis EFTu and Hsp70 induced systemic and mucosal antibody responses in American bison but failed to fully protect against Mycoplasma bovis challenge. Veterinary Microbiology. 309. Article 110680. https://doi.org/10.1016/j.vetmic.2025.110680.

Influence of the casein genotype in goat milk bioactivity: an in silico analysis of casein peptidome - (Peer Reviewed Journal)
Rubio-Reyes, A.Y., Delgado-Enciso, I., Casas, E., Garza-Brenner, E., Sifuentes-Rincon, A.M. 2025. Influence of the casein genotype in goat milk bioactivity: an in silico analysis of casein peptidome. Molecules. 30(12). Article 2601. https://doi.org/10.3390/molecules30122601.

Comparative innate immune responses of bison and cattle to Mannheimia haemolytica wildtype and LPS sialylation-deficient mutant strain - (Peer Reviewed Journal)
Menghwar, H., Boggiatto, P.M., Olsen, S.C., Slate, J., Goldkamp, A.K., Kanipe, C.R., Kaplan, B.S., Nielsen, D.W., Tatum, F.M., Casas, E., Dassanayake, R.P. 2025. Comparative innate immune responses of bison and cattle to Mannheimia haemolytica wildtype and LPS sialylation-deficient mutant strain. Research in Veterinary Science. 193. Article 105764. https://doi.org/10.1016/j.rvsc.2025.105764.

Altered germinal center responses in mice vaccinated with highly pathogenic avian influenza A(H5N1) virus - (Peer Reviewed Journal)
Seiler, P., Kaplan, B.S., Brice, D.C., Duan, S., Li, L., Mcgargill, M.A., Lee, N., Lin, C., Keating, R., Govorkova, E.A., Webby, R.J. 2025. Altered germinal center responses in mice vaccinated with highly pathogenic avian influenza A(H5N1) virus. Vaccine. 60. Article 127311. https://doi.org/10.1016/j.vaccine.2025.127311.

Mucosal colonization of Mannheimia haemolytica capsular and adhesin mutants in cattle - (Peer Reviewed Journal)
Goldcamp, A.K., Menghwar, H., Kanipe, C.R., Briggs, R., Chriswell, B.O., Casas, E., Clawson, M.L., Tatum, F.M., Dassanayake, R.P. 2025. Mucosal colonization of Mannheimia haemolytica capsular and adhesin mutants in cattle. Microbiology Spectrum. Article e00684-25. https://doi.org/10.1128/spectrum.00684-25.

Host transcriptome response to Mycoplasma bovis and bovine viral diarrhea virus in bovine tissues - (Peer Reviewed Journal)
Goldkamp, A.K., Atchison, R.G., Falkenberg, S.M., Dassanayake, R.P., Niell, J.D., Casas, E. 2025. Host transcriptome response to Mycoplasma bovis and bovine viral diarrhea virus in bovine tissues. BMC Genomics. 26. Article 361. https://doi.org/10.1186/s12864-025-11549-2.

Pasteurella multocida filamentous hemagglutinin B1 (fhaB1) gene is not involved with avian fowl cholera pathogenesis in turkey poults - (Peer Reviewed Journal)
Dassanayake, R.P., Briggs, R.E., Kaplan, B.S., Menghwar, H., Kanipe, C.R., Casas, E., Tatum, F.M. 2025. Pasteurella multocida filamentous hemagglutinin B1 (fhaB1) gene is not involved with avian fowl cholera pathogenesis in turkey poults. BMC Veterinary Research. 21(1). Article 207. https://doi.org/10.1186/s12917-025-04668-1.

Mannheimia haemolytica isogenic capsular and LPS-sialylation gene deletion mutants are attenuated in a calf lung challenge model - (Peer Reviewed Journal)
Menghwar, H., Tatum, F.M., Briggs, R.E., Goldkamp, A.K., Chriswell, B.O., Kanipe, C.R., Ma, H., Casas, E., Dassanayake, R.P. 2025. Mannheimia haemolytica isogenic capsular and LPS-sialylation gene deletion mutants are attenuated in a calf lung challenge model. Microbiology Spectrum. 13(6). Article e00283-25. https://doi.org/10.1128/spectrum.00283-25.

Mycoplasma leachii strain PG50 has reduced adherence to epithelial cells compared to Mycoplasma (Mycoplasmopsis) bovis strains - (Abstract Only)

Mycoplasma bovis outbreak and maintenance of subclinical infections in an exposed cohort of juvenile American bison (Bison bison) - (Peer Reviewed Journal)
Buttke, D.E., Schwartz, K., Schwalbe, E., Killion, H., Sondgeroth, K., Kaplan, B.S., Malmberg, J. 2025. Mycoplasma bovis outbreak and maintenance of subclinical infections in an exposed cohort of juvenile American bison (Bison bison). Journal of Wildlife Diseases. 61(3):563-573. https://doi.org/10.7589/JWD-D-24-00117.

Transfer RNA-derived fragment production in calves challenged with Mycoplasma bovis or co-infected with bovine viral diarrhea virus and Mycoplasma bovis in several tissues and blood - (Peer Reviewed Journal)
Goldkamp, A.K., Atchison, R.G., Falkenberg, S.M., Dassanayake, R.P., Niell, J.D., Casas, E. 2024. Transfer RNA-derived fragment production in calves challenged with Mycoplasma bovis or co-infected with bovine viral diarrhea virus and Mycoplasma bovis in several tissues and blood. Frontiers in Veterinary Science. 11. Article 1463431. https://doi.org/10.3389/fvets.2024.1463431.

Complete hybrid genome assembly of Mannheimia haemolytica serotype A2 strain D95 isolated from ovine lung - (Peer Reviewed Journal)
Goldkamp, A.K., Menghwar, H., Dassanayake, R.P., Tatum, F.M., Briggs, R.E., Casas, E. 2024. Complete hybrid genome assembly of Mannheimia haemolytica serotype A2 strain D95 isolated from ovine lung. Microbiology Resource Announcements. 13. Article e0055224. https://doi.org/10.1128/mra.00552-24.

Characterization of Histophilus somni sialic acid uptake mutant (delta-nanP/delta-nanU) using a mouse septicemia and mortality model - (Peer Reviewed Journal)
Menghwar, H., Tatum, F.M., Briggs, R.E., Kanipe, C.R., Casas, E., Kaptur, J.A., Kaplan, B.S., Inzana, T.J., Azadi, P., Dassanayake, R.P. 2024. Characterization of Histophilus somni sialic acid uptake mutant (delta-nanP/delta-nanU) using a mouse septicemia and mortality model. Microbial Pathogenesis. 194. Article 106839. https://doi.org/10.1016/j.micpath.2024.106839.

Complete genome sequence of a Histophilus somni Strain 91 isolated from a beef calf with pneumonia - (Peer Reviewed Journal)
Menghwar, H., Ma, H., Briggs, R.E., Tatum, F.M., Casas, E., Dassanayake, R.P. 2024. Complete genome sequence of a Histophilus somni Strain 91 isolated from a beef calf with pneumonia. Microbiology Resource Announcements. 13(10). Article e00570-24. https://doi.org/10.1128/mra.00570-24.

An injectable subunit vaccine containing Elongation Factor Tu and Heat Shock Protein 70 protects North American bison from Mycoplasma bovis infection - (Peer Reviewed Journal)
Kaplan, B.S., Dassanayake, R.P., Briggs, R.E., Kanipe, C.R., Boggiatto, P.M., Crawford, L., Olsen, S.C., Menghwar, H., Casas, E., Tatum, F.M. 2024. An injectable subunit vaccine containing Elongation Factor Tu and Heat Shock Protein 70 protects North American bison from Mycoplasma bovis infection. Frontiers in Veterinary Science. 11. Article 1408861. https://doi.org/10.3389/fvets.2024.1408861.

Analysis of nonsynonymous SNPs in candidate genes that influence bovine temperament and evaluation of their effect in Brahman cattle - (Peer Reviewed Journal)
Ruiz-De La Cruz, G., Sifuentes-Rincon, A.M., Paredes-Sanchez, F.A., Parra-Bracamontes, G.M., Casas, E., Riley, D.G., Perry, G.A., Welsh Jr., T.H., Randel, R.D. 2024. Analysis of nonsynonymous SNPs in candidate genes that influence bovine temperament and evaluation of their effect in Brahman cattle. Molecular Biology Reports. 51(1). Article 285. https://doi.org/10.1007/s11033-024-09264-4.

Transcriptomic profiles of Mannheimia haemolytica planktonic and biofilm associated cells - (Peer Reviewed Journal)
Ma, H., Alt, D.P., Falkenberg, S.M., Briggs, R.E., Tatum, F.M., Clawson, M.L., Casas, E., Dassanayake, R.P. 2024. Transcriptomic profiles of Mannheimia haemolytica planktonic and biofilm associated cells. PLOS ONE. 19(2). Article e0297692. https://doi.org/10.1371/journal.pone.0297692.

Immune responses to influenza D virus in calves previously infected with bovine viral diarrhea virus - (Peer Reviewed Journal)
Bauermann, F.V., Falkenberg, S., Rudd, J.M., Peter, C.M., Merchiratto, I., Ritchey, J.W., Gilliam, J., Taylor, J., Ma, H., Maggiolo, M.F. 2023. Immune responses to influenza D virus in calves previously infected with bovine viral diarrhea virus. Viruses. 15(12). Article 2442. https://doi.org/10.3390/v15122442.

Enhanced phagocytosis and complement-mediated killing of Mannheimia haemolytica serotype 1 following in-frame CMP-sialic acid synthetase (neuA) gene deletion - (Peer Reviewed Journal)
Menghwar, H., Tatum, F.M., Briggs, R.E., Casas, E., Kaplan, B.S., Azadi, P., Dassanayake, R.P. 2023. Enhanced phagocytosis and complement-mediated killing of Mannheimia haemolytica serotype 1 following in-frame CMP-sialic acid synthetase (neuA) gene deletion. Microbiology Spectrum. Article e0294423. https://doi.org/10.1128/spectrum.02944-23.

Differential identification of Mannheimia haemolytica genotypes 1 and 2 using colorimetric loop-mediated isothermal amplification - (Peer Reviewed Journal)
Dassanayake, R.P., Clawson, M.L., Tatum, F.M., Briggs, R.E., Kaplan, B.S., Casas, E. 2023. Differential identification of Mannheimia haemolytica genotypes 1 and 2 using colorimetric loop-mediated isothermal amplification. BMC Research Notes. 16. Article 4. https://doi.org/10.1186/s13104-023-06272-8.

NK-lysin antimicrobial peptide-functionalized nanoporous alumina membranes as biosensors for label-free bacterial endotoxin detection - (Peer Reviewed Journal)
Jiang, N., Shrotriya, P., Dassanayake, R.P. 2022. NK-lysin antimicrobial peptide-functionalized nanoporous alumina membranes as biosensors for label-free bacterial endotoxin detection. Biochemical and Biophysical Research Communications. 636:18-23. https://doi.org/10.1016/j.bbrc.2022.10.097.

Comparative study of antibacterial activity and stability of D-enantiomeric and L-enantiomeric bovine NK-lysin peptide NK2A - (Peer Reviewed Journal)
Dassanayake, R.P., Porter, T.J., Samorodnitsky, D., Falkenberg, S.M., Nicholson, E.M., Tatum, F.M., Briggs, R.E., Palmer, M.V., Casas, E. 2022. Comparative study of antibacterial activity and stability of D-enantiomeric and L-enantiomeric bovine NK-lysin peptide NK2A. Biochemical and Biophysical Research Communications. 595:76-81. https://doi.org/10.1016/j.bbrc.2022.01.071.