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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Meat Safety and Quality » Research » Research Project #437880

Research Project: Investigating the Emergence and Ecology of Antimicrobial Resistance in High Risk Beef Cattle

Location: Meat Safety and Quality

Project Number: 3040-32000-035-003-R
Project Type: Reimbursable Cooperative Agreement

Start Date: May 15, 2020
End Date: May 14, 2025

The objectives of the research are to understand the emergence and ecology of antimicrobial resistance in beef cattle production in high health risk cattle at receipt to the feedlot following metaphylactic treatment, and to evaluate novel management approaches to reduce the need and use of antibiotics in feedlot production systems.

ARS investigators at USMARC will analyze samples collected from high health risk beef cattle to determine the potential role that metaphylactic and therapeutic antimicrobials may play in the dissemination of antibiotic resistance in commensal and pathogenic bacteria. Furthermore, effective antibiotics that generate the least antimicrobial resistance will be further evaluated in follow-up studies with targeted treatment based on individual animal health to determine if further targeted metaphylactic treatment provides a reduction to antibiotic resistance. ARS scientists will analyze samples of feces from these cattle to monitor for antibiotic resistant E. coli and Salmonella, and provide a sub-sample to UNL for sequencing.