Research Project: Exploiting Nutrition and Protein Quality Controls to Delay Age-related Macular Degeneration and Cataracts

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Repurposing a cyclin dependent kinase 1 (CDK1) mitotic regulatory network to complete terminal differentiation in lens fiber cells - (Peer Reviewed Journal)
Taylor, A., Gu, Y., Chang, M., Yang, W., Francisco, S., Rowan, S., Bejarano, E., Pruitt, S., Zhu, L., Weiss, G., Brennan, L., Kantorow, M., Whitcomb, E. 2023. Repurposing a cyclin dependent kinase 1 (CDK1) mitotic regulatory network to complete terminal differentiation in lens fiber cells. Investigative Ophthalmology and Visual Science. 64(2). https://doi.org/10.1167/iovs.64.2.6.

Proteostasis in aging-associated ocular disease - (Review Article)
Weinberg, J., Gaur, M., Swaroop, A., Taylor, A. 2022. Proteostasis in aging-associated ocular disease. Molecular Aspects of Medicine. https://doi.org/10.1016/j.mam.2022.101157.

Boosting proteolytic pathways as a treatment against glycation-derived damage in the brain? - (Review Article)
Taylor, A., Bejarano-Fernandezel, E. 2021. Boosting proteolytic pathways as a treatment against glycation-derived damage in the brain?. Neural Regeneration Research. 17(2):320-322. https://doi.org/10.4103/1673-5374.317971.

Alterations to the gut microbiome impair bone tissue strength in aged mice - (Peer Reviewed Journal)
Macy, C., Smith, K.M., Nixon, J.C., Hernandez, C.J., Rowan, S. 2021. Alterations to the gut microbiome impair bone tissue strength in aged mice. Bone Reports. 14:101065. https://doi.org/10.1016/j.bonr.2021.101065.

Glyoxalase system as a therapeutic target against diabetic retinopathy - (Review Article)
Aragones, G., Rowan, S., Francisco, S.G., Yang, W., Weinberg, J., Taylor, A., Bejarano, E. 2020. Glyoxalase system as a therapeutic target against diabetic retinopathy. Antioxidants. 9(11):1062. https://doi.org/10.3390/antiox9111062.

Generation and characterization of anti-glucosepane antibodies enabling direct detection of glucosepane in retinal tissue - (Peer Reviewed Journal)
Streeter, M.D., Rowan, S., Ray, J., McDonald, D.M., Volkin, J., Clark, J., Taylor, A., Spiegel, D.A. 2020. Generation and characterization of anti-glucosepane antibodies enabling direct detection of glucosepane in retinal tissue. ACS Chemical Biology. 15(10):2655-2661. https://doi.org/10.1021/acschembio.0c00093.

Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases - (Review Article)
Francisco, S.G., Smith, K.M., Aragones, G., Whitcomb, E., Weinberg, J., Wang, X., Bejarano-Fernandez, E., Taylor, A., Rowan, S. 2020. Dietary patterns, carbohydrates, and age-related eye diseases. Nutrients. https://doi.org/10.3390/nu12092862.

Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability - (Peer Reviewed Journal)
Aragones, G., Dasuri, K., Olukorede, O., Francisco, S.G., Renneburg, C., Kumsta, C., Hansen, M., Kageyama, S., Komatsu, M., Rowan, S., Volkin, J., Workman, M., Yang, W., Daza, P., Ruano, D., Dominguez-Martin, H., Rodriguez-Navarro, J.A., Du, X., Brownlee, M.A., Bejarano, E., Taylor, A. 2020. Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability. Aging Cell. https://doi.org/10.1111/acel.13257.

Dietary starch composition effects on Cx43-intercellular communication channels and short-term memory - (Abstract Only)
Francisco, S., Smith, K., Rowan, S., Aragones Bargallo, G., Smith, D.E., Shukitt Hale, B., Taylor, A., Bejarano Fernandez, E. 2020. Dietary starch composition effects on Cx43-intercellular communication channels and short-term memory. Current Developments in Nutrition. 4(2):1205. https://doi.org/10.1093/cdn/nzaa057_021.

The interaction of gut microbiota composition and dietary starch form on gut health in aged mice - (Abstract Only)
2020. The interaction of gut microbiota composition and dietary starch form on gut health in aged mice. Current Developments in Nutrition. 4(Suppl_2):1585. https://doi.org/10.1093/cdn/nzaa062_042.

A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration - (Peer Reviewed Journal)
Rowan, S., Jiang, S., Chang, M., Volkin, J., Cassalman, C., Smith, K.M., Streeter, M.D., Spiegel, D.A., Moreira-Neto, C., Rabbani, N., Thornalley, P.J., Smith, D.E., Waheed, N.K., Taylor, A., Jiang, S. 2020. A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration. Free Radical Biology and Medicine. 150:75-86. https://doi.org/10.1016/j.freeradbiomed.2020.02.010.

Mechanistic targeting of advanced glycation end-products in age-related diseases - (Review Article)
Rowan, S., Bejarano-Fernandez, E., Taylor, A. 2018. Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochimica et Biophysica Acta. 1864(12):3631-3643. https://doi.org/10.1016/j.bbadis.2018.08.036.