Liping Huang
Research Geneticist
Publications
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Submission of genetic variant information of the human ZNT7 gene and updating the ClinVar database
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Huang, L., Ziegler, A. 2023. Submission of genetic variant information of the human ZNT7 gene and updating the ClinVar database. Clin Var. VCV001711192.3. https://www.ncbi.nlm.nih.gov/clinvar/variation/1711192/?oq=SCV002578244&m=NM_133496.5(SLC30A7):c.21dup%20(p.Asp8fs)
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Submission of information on a newly discovered genetic genetic disease, namely Zieglar-Huang Syndrome, to the OMIM database
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Huang, L., Ziegler, A. 2023. Submission of information on a newly discovered genetic genetic disease, namely Zieglar-Huang Syndrome, to the OMIM database. An Online Catalog of Human Genes and Genetic Disorders (OMIM). 620501. https://www.omim.org/entry/620501?search=slc30a7&highlight=slc30a7.
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Association of estimated daily lactose consumption, lactase persistence genotype (rs4988235), and gut microbiota in healthy adults in the United States
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(Peer Reviewed Journal)
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Kable, M.E., Chin, E., Huang, L., Stephensen, C.B., Lemay, D.G. 2023. Association of estimated daily lactose consumption, lactase persistence genotype (rs4988235), and gut microbiota in healthy adults in the United States. Journal of Nutrition. 153(8):2163-2173. https://doi.org/10.1016/j.tjnut.2023.06.025.
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Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults
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(Peer Reviewed Journal)
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Yang, Z., Wang, Y.E., Kirschke-Schneide, C.P., Stephensen, C.B., Newman, J.W., Keim, N.L., Cai, Y., Huang, L. 2023. Effects of a genetic variant rs13266634 in the zinc transporter 8 gene (SLC30A8) on insulin and lipid levels before and after a high-fat mixed macronutrient tolerance test in U.S. adults. Journal of Trace Elements in Medicine and Biology. 77. Article 127142. https://doi.org/10.1016/j.jtemb.2023.127142.
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Identification of novel compound heterozygous variants in the SLC30A7 (ZNT7) gene in two French brothers with stunted growth, testicular hypoplasia and bone marrow failure
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(Peer Reviewed Journal)
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Huang, L., Yang, Z., Kirschke-Schneide, C.P., Prouteau, C., Copin, M., Bonneau, D., Pellier, I., Coutant, R., Miot, C., Ziegler, A. 2023. Identification of novel compound heterozygous variants in the SLC30A7 (ZNT7) gene in two French brothers with stunted growth, testicular hypoplasia and bone marrow failure. Human Molecular Genetics. 32(12):2016-2031. https://doi.org/10.1093/hmg/ddad033.
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Trimethylamine N-Oxide response to a mixed macronutrient tolerance test in a cohort of United States adults
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(Peer Reviewed Journal)
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James, K.L., Gertz, E.R., Kirschke-Schneide, C.P., Allayee, H., Huang, L., Kable, M.E., Newman, J.W., Stephensen, C.B., Bennett, B.J. 2023. Trimethylamine N-Oxide response to a mixed macronutrient tolerance test in a cohort of United States adults. International Journal of Molecular Sciences. 24(3). Article 2074. https://doi.org/10.3390/ijms24032074.
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SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults
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(Peer Reviewed Journal)
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Wang, Y.E., Kirschke-Schneide, C.P., Woodhouse, L.R., Bonnel, E.L., Stephensen, C.B., Bennett, B.J., Newman, J.W., Keim, N.L., Huang, L. 2022. SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults. Biomed Central (BMC) Nutrition. 8. Article 95. https://doi.org/10.1186/s40795-022-00592-x.
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The Znt7-null mutation has sex dependent effects on the gut microbiota and goblet cell population in the mouse colon
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(Peer Reviewed Journal)
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Kable, M.E., Riazati, N., Kirschke, C.P., Zhao, J., Tepaamorndech, S., Huang, L. 2020. The Znt7-null mutation has sex dependent effects on the gut microbiota and goblet cell population in the mouse colon. PLoS ONE. 15(9). Article e0239681. https://doi.org/10.1371/journal.pone.0239681.
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Association of estimated daily lactose consumption, lactase persistence genotype (rs4988235), and gut microbiota in healthy U.S. adults
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(Abstract Only)
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Kable, M.E., Chin, E.L., Huang, L., Stephensen, C.B., Lemay, D.G. 2020. Association of estimated daily lactose consumption, lactase persistence genotype (rs4988235), and gut microbiota in healthy U.S. adults. Current Developments in Nutrition. 4/2/1566. https://doi.org/10.1093/cdn/nzaa062_023.
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Estimated daily Lactose consumption in healthy U.S. adults in relation to lactase persistence genotype (rs4988235)
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(Abstract Only)
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Association of lactase persistence genotypes (rs4988235) and ethnicity with dairy intake in a healthy U.S. population
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(Peer Reviewed Journal)
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Chin, E.L., Huang, L., Bouzid, Y.Y., Kirschke, C.P., Durbin-Johnson, B., Baldiviez, L.M., Bonnel, E.L., Keim, N.L., Korf, I., Stephensen, C.B., Lemay, D.G. 2019. Association of lactase persistence genotypes (rs4988235) and ethnicity with dairy intake in a healthy U.S. population. Nutrients. 11(8):1860. https://doi.org/10.3390/nu11081860.
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Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal
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(Peer Reviewed Journal)
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Lemay, D.G., Huang, S., Huang, L., Alkan, Z., Kirschke, C.P., Burnett, D.J., Wang, Y., Hwang, D.H. 2019. Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal. Journal of Nutritional Biochemistry. 72:108209. https://doi.org/10.1016/j.jnutbio.2019.06.007.
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Subcongenic analysis of a quantitative trait locus affecting body weight and glucose metabolism in zinc transporter 7 (znt7)-knockout mice
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Huang, L., Tepaamorndech, S., Kirschke, C.P., Cai, Y., Zhao, J., Cao, X., Rao, A. 2019. Subcongenic analysis of a quantitative trait locus affecting body weight and glucose metabolism in zinc transporter 7 (znt7)-knockout mice. BioMed Central (BMC) Genetics. 20:19. https://doi.org/10.1186/s12863-019-0715-2.
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SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the ß-cells
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(Peer Reviewed Journal)
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Cai, Y., Kirschke, C.P., Huang, L. 2018. SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the ß-cells. Journal of Molecular Histology. 49(2):133-145. https://doi.org/10.1007/s10735-017-9753-0.
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Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults
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(Peer Reviewed Journal)
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Baldiviez, L.M., Keim, N.L., Laugero, K.D., Hwang, D.H., Huang, L., Woodhouse, L.R., Burnett, D.J., Zerofsky, M., Bonnel, E., Allen, L.H., Newman, J.W., Stephensen, C.B. 2017. Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults. Biomed Central (BMC) Nutrition. 3(79):1-13. https://doi.org/10.1186/s40795-017-0197-4.
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Aberrant fatty acid metabolism in the skeletal muscle contributes to insulin resistance in zinc transporter 7 (Znt7) knockout mice
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(Peer Reviewed Journal)
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Huang, L., Tepaamorndech, S., Kirschke, C.P., Newman, J.W., Keyes, W.R., Pedersen, T.L. 2018. Aberrant fatty acid metabolism in the skeletal muscle contributes to insulin resistance in zinc transporter 7 (Znt7) knockout mice. Journal of Biological Chemistry. 293(20):7549-7563. doi:10.1074/jbc.M117.817692.
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ZNT7 binds to CD40 and influences CD154-triggered p38 MAPK activity in B lymphocytes-a possible regulatory mechanism for zinc in immune function
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Tepaamorndech, S., Oort, P.J., Kirschke, C.P., Yimeng, C., Huang, L. 2017. ZNT7 binds to CD40 and influences CD154-triggered p38 MAPK activity in B lymphocytes-a possible regulatory mechanism for zinc in immune function. FEBS Open Bio. 7(5):675–690. doi: 10.1002/2211-5463.12211.
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Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival
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Huang, L., Kirschke, C.P. 2016. Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival. Austin Journal of Endocrinology and Diabetes. 3:1037.
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Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival.
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Huang, L., Kirschke, C.P. 2016. Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival.. Austin Journal of Endocrinology and Diabetes. 3(1):1-8.
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Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activity and glucose uptake
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(Peer Reviewed Journal)
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Tepaamorndech, S., Kirschke, C.P., Pedersen, T.L., Keyes, W.R., Newman, J.W., Huang, L. 2015. Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activity and glucose uptake. FEBS Journal. 283(2):378-394. doi: 10.1111/febs.13582.
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Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice
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(Peer Reviewed Journal)
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Zinc
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Huang, L., Drake, V.J., Ho, E. 2015. Zinc. Advances in Nutrition. 6:224-226.
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Zinc and its transporters, pancreatic beta cells, and insulin metabolism
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Huang, L. 2014. Zinc and its transporters, pancreatic beta cells, and insulin metabolism. In: Litwack, G. editor. Vitamins and Hormones. Atlanta, GA: Elsevier. p.365-390.
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The SLC30 family of zinc transporters – a review of current understanding of their biological and pathophysiological roles
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Huang, L., Tepaamorndech, S. 2013. The SLC30 family of zinc transporters – a review of current understanding of their biological and pathophysiological roles. European Journal of Applied Physiology. 34(2-3):548-560.
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Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice and selectively lowers plasma C-reactive protein in lean mice
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(Peer Reviewed Journal)
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Parelman, M.A., Storms, D.H., Kirschke, C.P., Huang, L., Zunino, S.J. 2012. Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice and selectively lowers plasma C-reactive protein in lean mice. British Journal of Nutrition. 1-11. DOI: 10.1017/S0007114512000037.
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Diet-influenced chromatin modification and expression of chemopreventive genes by the soy peptide, lunasin
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Galvez, A., Huang, L., Magbanua, M.M., Dawson, K., Nandi, S., Rodriguez, R.L. 2011. Diet-influenced chromatin modification and expression of chemopreventive genes by the soy peptide, lunasin. In: Bidlack, W.R., Rodriguez, R.L., editors. Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease. Taylor and Francis Group. 25-40.
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A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model
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(Peer Reviewed Journal)
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Tepaamorndech, S., Huang, L., Kirschke, C.P. 2011. A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model. Cancer Letters. 308 (2011) 33-42.
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Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription
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Huang, L., Mi, Y., Kirschke, C.P. 2010. Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription. Experimental Cell Research. 2010 Volume 316, Issue 16 2630-2643
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Expression of ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation
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(Peer Reviewed Journal)
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Kirschke, C.P., Huang, L. 2008. Expression of ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation. Journal of Histochemistry and Cytochemistry (2008) 39:359-370.
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Expression of zinc transporter ZnT7 in mouse superior cervical ganglion
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(Peer Reviewed Journal)
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Gao, H., Xu, H., Wang, X., Dahlstrom, A., Huang, L., Wang, Z. 2008. Expression of zinc transporter ZnT7 in mouse superior cervical ganglion. Autonomic Neuroscience: Basic & Clinical, 140 (2008) 59-65.
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The cellular and subcellular localization of zinc transporter 7 in the mouse spinal cord
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(Peer Reviewed Journal)
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Chi, Z., Ren, H., Wang, X., Rong, M., Huang, L., Wang, Z. 2008. The cellular and subcellular localization of zinc transporter 7 in the mouse spinal cord. Histology and Histopathology Cellular and Molecular Biology, Vol.23:781-787
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Abundant Expression of Zinc Transporters in the Amyloid Plaques of Alzheimer’s Disease Brain
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Zhang, L., Wang, X., Stoltenberg, M., Danscher, G., Huang, L., Wang, Z. 2008. Abundant Expression of Zinc Transporters in the Amyloid Plaques of Alzheimer’s Disease Brain. Elsevier. Brain Research Bulletin 77 (2008) 55-60.
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ALTERED EXPRESSION AND DISTRIBUTION OF ZINC TRANSPORTERS IN APP/PS1 TRANSGENIC MOUSE BRAIN
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(Peer Reviewed Journal)
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Zhang, L., Wang, X., Zheng, Z., Ren, H., Stoltenberg, M., Danscher, G., Huang, L., Rong, M., Wang, Z. 2008. Altered expression and distribution of zinc transporters in app/ps1 transgenic mouse brain. Elsevier, Journal Neurobiology of Aging, Doi:10,1016:1-14, 2008.
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Znt7 (Slc30a7)-DEFICIENT MICE DISPLAY REDUCED BODY ZINC STATUS AND BODY FAT ACCUMULATION
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(Peer Reviewed Journal)
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Huang, L., Yu, Y., Kirschke, C.P., Gertz, E.R., Kent K.C., L. 2008. Znt7 (Slc30a7)-Deficient Mice Display Rreduced Body ZincC Status and Body Fat Accumulation. Journal of Biological Chemistry. 282,51:37053-37063, 2007.
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Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root ganglia
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(Peer Reviewed Journal)
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Zhang, L., Chi, Z., Ren, H., Rong, M., Dahlstrom, A., Huang, L., Wang, Z. 2007. Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root ganglia. Elsevier. Brain Research Bulletin 74 (2007) 278-283.
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A DI-LEUCINE SORTING SIGNAL IN ZIP1 (SLC39A1) MEDIATES ENDOCYTOSIS OF THE PROTEIN
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(Peer Reviewed Journal)
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Huang, L., Kirschke, C.P. A di-leucine sorting signal in zip1 (slc39a1) mediates endocytosis of the protein. FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETY, 274: 3986-3997, 2007.
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Localization of ZnT7 and zinc ions in mouse retina-Immunohistochemistry and selenium autometallography
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Wang, X., Wang, Z., Gao, H., Danscher, G., Huang, L. Localization of ZnT7 and zinc ions in mouse retina-Immunohistochemistry and selenium autometallography. Brain Research Bulletin, 2006.71:91-96
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IMMUNOHISTOCHEMICAL ANALYSIS OF ZNT1, 4, 5, 6, AND 7 IN THE MOUSE GASTROINTESTINAL TRACT
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(Peer Reviewed Journal)
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Yu, Y.Y., Kirschke, C.P., Huang, L. 2006. IMMUNOHISTOCHEMICAL ANALYSIS OF ZNT1, 4, 5, 6, AND 7 IN THE MOUSE GASTROINTESTINAL TRACT. Journal of Histochemistry and Cytochemistry. Vol. 55(3):223-234, 2006.
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Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells
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(Peer Reviewed Journal)
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Chi, Z., Wang, X., Wang, Z., Gao, H., Dahlstrom, A., Huang, L. 2006. Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells. NeuroReport. 2006. Vol.17:1807-1811.
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DECREASED INTRACELLULAR ZINC IN HUMAN TUMORIGENIC PROSTATE EPITHELIAL CELLS: A POSSIBLE ROLE IN PROSTATE CANCER PROGRESSION
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(Peer Reviewed Journal)
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Huang, L., Kirschke, C.P., Zhang, Y. Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression. Cancer Cell International 2006, 6:10, 2006.
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NUTRIENT-GENE INTERACTIONS INVOLVING SOY PEPTIDE AND CHEMOPREVENTIVE GENES IN PROSTATE EPITHELIAL CELLS
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(Peer Reviewed Journal)
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Magvanua, M.J., Dawson, K., Huang, L., Malyj, W., Gregg, J., Galvez, A.F., Rodriguez, R.L. 2006. NUTRIENT-GENE INTERACTIONS INVOLVING SOY PEPTIDE AND CHEMOPREVENTIVE GENES IN PROSTATE EPITHELIAL CELLS. John Wiley & Sons, Inc. Chapter 11:255-276.
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ZIP7 GENE (SLC39A7) ENCODES A ZINC TRANSPORTER INVOLVED IN ZINC HOMEOSTASIS OF THE GOLGI APPARATUS
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Huang, L., Kirschke, C.P., Zhang, Y., Yu, Y. 2005. ZIP7 GENE (SLC39A7) ENCODES A ZINC TRANSPORTER INVOLVED IN ZINC HOMEOSTASIS OF THE GOLGI APPARATUS. Journal of Biological Chemistry 280(15):15456-15463, 2005.
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ABUNDANT EXPRESSION OF ZINC TRANSPORTERS IN BERGMAN GLIA OF MOUSE CEREBELLUM
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(Peer Reviewed Journal)
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Wang, Z., Stoltenberg, M., Huang, L., Danscher, G., Dahlstrom, A., Shi, Y., Li, J. 2004. ABUNDANT EXPRESSION OF ZINC TRANSPORTERS IN BERGMAN GLIA OF MOUSE CEREBELLUM. Elsevier. Bulletin 64:441-44, 2004.
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DYNAMIC ZINC POOLS IN MOUSE CHOROID PLEXUS
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(Peer Reviewed Journal)
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Wang, Z., Stoltenberg, M., Jo, S.M., Huang, L., Larsen, A., Dahlstrom, A., Danscher, G. 2004. Dynamic zinc pools in mouse choroid plexus. NeuroReport, 15:1801-1804, Lippincott, Williams & Wilkins.
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INVESTIGATION OF LYMPHOCYTE GENE EXPRESSION FOR USE AS BIOMARKERS FOR ZINC STATUS IN HUMANS
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(Peer Reviewed Journal)
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Andree, K.B., Kim, J., Kirschke, C.P., Gregg, J.P., Paik, H., Joung, H., Woodhouse, L.R., King, J., Huang, L. 2004. Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans. Journal of Nutrition. Journal of Nutrition. 134:1716-1723, 2004.
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ZNT7, A NOVEL MAMMALIAN ZINC TRANSPORTER, ACCUMULATES ZINC IN THE GOLGI APPARATUS
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(Peer Reviewed Journal)
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Kirschke, C.P., Huang, L. 2004. Znt7, a novel mammalian zinc transporter, accumulates zinc in the golgi apparatus. Journal of Biological Chemistry. 278:4096-103, 2004.
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EFFLUX AND COMPARTMENTALIZATION OF ZINC BY MEMBERS OF THE SLC30 FAMILY OF SOLUTE CARRIERS
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(Peer Reviewed Journal)
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Palmiter, R.D., Huang, L. 2004. Efflux and compartmentalization of zinc by members of the slc30 family of solute carriers. Journal of Physiology (2004) 447:744-51.
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