Submitted to: US-Japan Coop Pgm on Dev and Util of Natural Products Abstracts Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 10/25/1996
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: Bovine viral diarrhea virus is a member of the Pestivirus genus within the Flavivirus family. It is an important pathogen of cattle worldwide causing a spectrum of diseases ranging from subclinical to highly fatal. Recently BVDV has been assigned to two different genotypes, BVDV 1 and BVDV 2, based on comparison of the 5' UTR. These genotypes are antigenically distinct based on serology, Mab binding, and vaccine breaks. A severe peracute disease with high mortality, termed hemorrhagic syndrome, has been associated with viruses from the BVDV 2 genotype but not the BVDV 1 genotype. Two PCR-based tests were developed at the NADC to differentiate between BVDV 1 and BVDV 2. Researchers at the Diagnostic Virology Laboratory of the National Veterinary Services Laboratories utilized these primers to type BVDV isolates from case submissions dating back to 1979. While a higher percentage of BVDV were typed as BVDV 2 in 1994 and 1995, BVDV 2 viruses were isolated from 1979 through the present. In addition, infection with BVDV 2 viruses was not limited to the peracute/hemorrhagic syndrome seen in recent years but also with the traditional clinical signs associated with BVDV.