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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #59876
Title: UMBILICAL CORD LESIONS IN PORCINE FETUSES INFECTED WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS

Author
item Lager, Kelly
item HALBUR, PATRICK - IOWA STATE UNIVERSITY

Submitted to: North Central Conference of Veterinary Laboratory Diagnosticians
Publication Type: Proceedings
Publication Acceptance Date: 5/3/1995
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Diagnosis of porcine reproductive and respiratory syndrome (PRRS) virus-induced reproductive failure in swine is difficult because of the rapid inactivation of virus in fetuses that have died prior to abortion or farrowing. In this report, we describe gross and microscopic lesions of diagnostic value found in fetuses transplacentally infected with PRRS virus (PRRSV) during late gestation. Seven sows free of PRRSV-specific antibody and one sow (#8) that had been previously infected with PRRSV were oronasally exposed to a PRRSV inoculum at or about 90 days of gestation (DG). One control sow (#9) was oronasally exposed to a sham inoculum at 90 DG. Sows were euthanized 21 days-post-exposure and fetuses were tested for virus. Transplacental infection and umbilical cord lesions were found in litters 1 through 7; however, no infection or lesions were found in litters 8 and 9. The gross lesions in the umbilical cords ranged from segmental hemorrhagic areas 1 to 2 cm in length to a full length involvement of the cord which was grossly distended with frank hemorrhage. All live fetuses that had gross lesions in their umbilical cord were viremic and a necrotizing arteritis with periarterial hemorrhage was found in each cord by histopathological examination. This was the most consistent microscopic lesion in fetuses infected with PRRSV. Sows 1 through 7 had endometritis and myometritis of varying degrees suggesting PRRSV may induce these lesions as well. This study indicates careful gross and microscopic examination of the umbilical cord may aid in the diagnosis of PRRSV-induced reproductive failure.