Skip to main content
ARS Home » Midwest Area » Madison, Wisconsin » U.S. Dairy Forage Research Center » Cell Wall Biology and Utilization Research » Research » Publications at this Location » Publication #400630

Research Project: Developing Strategies to Improve Dairy Cow Performance and Nutrient Use Efficiency with Nutrition, Genetics, and Microbiology

Location: Cell Wall Biology and Utilization Research

Title: Genome-wide copy number variation and structural variation: A novel tool for improved livestock genomic selection

item Li, Wenli

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 9/23/2023
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Copy number variations (CNVs) are a major form of genomic variation in mammalian genomes. Due to their much larger size than single nucleotide polymorphisms (SNPs), they affect a significant portion of the genome via deletion, duplication, and translocation. SNPs have been the variant of choice in genomic prediction in livestock species. With the advancement of sequencing technologies and analytical algorithms, a significant number of CNVs have been associated with desirable production traits and disease phenotypes, making this form of genomic variant an attractive candidate for improved livestock genomic selection. In this review, the current CNVs associated with livestock production traits and diseases, and the obstacles of using CNVs for genomic selection are discussed. Finally, this review discusses how CNVs can be used in the future to improve livestock genomic selection.