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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #391361

Research Project: Energy Met.: Novel Approaches to Facilitating Successful Energy Regulation in Aging--Obesity & Met.: Role of Adipocyte Metabolism in the Development of Obesity and Associated Metabolic Complications

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Randomized trial of a novel lifestyle intervention compared with the Diabetes Prevention Program for weight loss in adult dependents of military service members

Author
item DAS, SAI KRUPA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item BUKHARI, ASMA - Us Army Research Institute Of Environmental Medicine
item TAETZSCH, AMY - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item ERNST, AMY - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item ROGERS, GAIL - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item GILHOOLY, CHERYL - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item HATCH-MCCHESNEY, ADRIENNE - Us Army Research Institute Of Environmental Medicine
item BLANCHARD, CAROLINE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item LIVINGSTON, KARA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item SILVER, RACHEL - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item MARTIN, EDWARD - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item MCGRAW, SUSAN - Us Army Research Institute Of Environmental Medicine
item CHIN, MEGHAN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item VAIL, TAYLOR - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item LUTZ, LAURA - Us Army Research Institute Of Environmental Medicine
item MONTAIN, SCOTT - Us Army Research Institute Of Environmental Medicine
item PITTAS, ANASTASSIOS - Tufts Medical Center
item LICHTENSTEIN, ALICE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item ALLISON, DAVID - Indiana University
item DICKINSON, STEPHANIE - Indiana University
item CHEN, XIWEI - Indiana University
item SALTZMAN, EDWARD - Tufts University
item YOUNG, ANDREW - Us Army Research Institute Of Environmental Medicine
item ROBERTS, SUSAN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: The American Journal of Clinical Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/14/2021
Publication Date: 8/10/2021
Citation: Das, S., Bukhari, A., Taetzsch, A.G., Ernst, A.K., Rogers, G., Gilhooly, C., Hatch-McChesney, A., Blanchard, C.M., Livingston, K.A., Silver, R., Martin, E., McGraw, S.M., Chin, M.K., Vail, T.A., Lutz, L.J., Montain, S.J., Pittas, A.G., Lichtenstein, A.H., Allison, D.B., Dickinson, S., Chen, X., Saltzman, E., Young, A.J., Roberts, S. 2021. Randomized trial of a novel lifestyle intervention compared with the Diabetes Prevention Program for weight loss in adult dependents of military service members. American Journal of Clinical Nutrition. 114(4):1546-1559. https://doi.org/10.1093/ajcn/nqab259.
DOI: https://doi.org/10.1093/ajcn/nqab259

Interpretive Summary: While behavior change programs are the preferred treatment for people with obesity, participant weight loss is typically low. In this study, we compared the effectiveness of two weight loss programs- the new Healthy Weight for Living program and a modified Diabetes Prevention Program- in adult dependents of military personnel who had overweight or obesity. Participants were randomly assigned to Healthy Weight for Living (121 participants) or modified Diabetes Prevention Program (117 participants). Both weight loss programs were delivered by video conference. Twelve-month changes in weight, as well as 6-month changes in diet and risk factors for disease, were measured in all participants. Healthy Weight for Living was well accepted and observed by participants and achieved impactful weight loss with benefits to markers of health similar to modified Diabetes Prevention Program. Our research identifies Healthy Weight for Living as a promising alternative approach for behavioral treatment of overweight and obesity.

Technical Abstract: Background. Lifestyle interventions are the first-line treatment for obesity, but participant weight loss is typically low. Objectives. We evaluated the efficacy of an alternative lifestyle intervention [Healthy Weight for Living (HWL)] compared with a modified Diabetes Prevention Program (m-DPP). HWL was based on a revised health behavior change model emphasizing hunger management and the development of healthy food preferences. m-DPP was a standard Diabetes Prevention Program implemented with counselor time matched to HWL. Participants were adult dependents of military personnel and had overweight or obesity. Methods. Participants were randomly assigned to HWL (n = 121) or m-DPP (n = 117), delivered primarily by group videoconference with additional midweek emails. The primary outcome was 12-mo weight change. Secondary outcomes included 6-mo changes in cardiometabolic risk factors and diet. Intention-to-treat (ITT) and complete case (CC) analyses were performed using linear mixed models. Results. Retention did not differ between groups (72% and 66% for HWL and m-DPP at 12 mo, respectively; P = 0.30). Mean +/- SE adjusted 12-mo weight loss in the ITT cohort was 7.46 +/- 0.85 kg for HWL and 7.32 +/- 0.87 kg for m-DPP (P = 0.91); in the CC cohort, it was 7.83 +/- 0.82 kg for HWL and 6.86 +/- 0.88 kg for m-DPP (P = 0.43). Thirty-eight percent of HWL and 30% of m-DPP completers achieved =10% weight loss (P = 0.32). Improvements in systolic blood pressure, LDL cholesterol, triglycerides, fasting glucose, general health, sleep, and mood were similar across groups; improvements in diastolic blood pressure were greater in m-DPP. Adjusted group mean reductions in energy intake were not significantly different between groups, but HWL participants were more adherent to their dietary prescription for lower glycemic index and high fiber and protein (P = 0.05 to <0.001 for ITT). Conclusions. HWL and m-DPP showed equivalent and clinically impactful mean weight loss with cardiometabolic benefits. These results identify an alternative approach for behavioral treatment of overweight and obesity.